A Statistical Approach to Genetic Epidemiology: Concepts and Applications
Andreas Ziegler, Inke R. Koenig
ISBN: 3-527-31252-8 - Hardcover - 361 pages
February 2006 - Wiley-VCH
Covering the latest developments, this advanced textbook is the first to focus on introducing the relevant statistical methods applied in this field. Written by the prize-winning scientist Andreas Ziegler, President of the German Region of the International Biometric Society, and Inke König, who contributes more than five years of teaching experience, this is ideal for epidemiologists, geneticists, statistics specialists, biomathematicians, and graduate students.
After providing a concise introduction to genetic fundamentals, the authors explain both linkage analysis and association analysis in detail. The textbook features more than 100 problems and solutions.
Table of Contents
Genetic Map Distances
Model Based Linkage Analysis
Model Free Linkage Analysis for Dichotomous Traits
Model Free Linkage Analysis for Quantitative Traits
Case-Control Association Analysis
Family-Based Association Analysis
Haplotypes in Association Analyses
Appendix: Algorithms Used in Linkage Analyses