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  Abstracts: A contig in Xq13.1  
  September 06, 1995

Neurogenetics

 
     

U. Peters(1), G. Haberhausen(1), H. Muth(1), A. Köhler(1), A.P. Monaco(2) and U. Müller(1)
 
(1) Institut für Humangenetik der Justus Liebig Universität, Schlangenzahl 14, 35392 Giessen, Germany; (2) Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, John Radcliff Hospital, Oxford, U.K.  

2nd Workshop Neurogenetics in Germany, Munich, October 19-21, 1995



Cloning of a given region of the genome in suitable vectors greatly facilitates the systematic isolation, identification and characterization of genes within this region. In order to identify candidate genes of the X-linked dystonia parkinsonism syndrome (XDP) we have constructed a YAC-contig of the critical region. The contig consists of 20 overlapping yeast artificial chromosomes (YACs received from CEPH, ICRF, University of Washington Library) and covers about 1.8 Mb. The exact location of the YACs was determined using 18 markers from Xq13.1. Of these 5 were published sequences and 13 were newly developed. The region was further delineated by studies of linkage analysis and of allelic association. A cosmid contig was constructed, which spans the region of the highest allelic association and was used for exon trapping in order to isolate unknown genes in Xq13.1.

Headings
X-linked dystonia parkinsonism syndrome (XDP)
Xq13.1

 
     
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