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Moving Ahead Rumen Modeling
Port Coquitlam BC V3B 1G3
Canada
Toll free: +011-604-945-8408
Phone: +011-604-945-8408
Fax: 16049419022
Description:
RUMEN MODELING RESEARCH INFORMATION ENTERPRISES. We are planning a larger project using quantitative estimations to elaborate prediction modeling from earlier NRC Guidelines or Principles to Ruminant Feeding Using Both Basic Feeding Rations for Forage, Concentrate and Pre-Mix and the resulting Nutrient Profile for Digestion Post-Ruminally. Modeling stipulates that: 1.) The Overall Schema is INtake = OUTputs (in dynamic equilibrium). 2.) It will require description of the Kinetics of Transport Processes given the Liquids, Solids and Nature of the Biofilms. 3.) It will require description of the Kinetics of Metabolic Rxn. Transformations with their Stochiometry. 4.) It will require knowledge of the Stochiometry of Biomass Synthesis, other Endproduct Synthesis and the Partitioned Escape Residuals from Feed INtake source. 5.) More complex are Bulk or Mass Transfer Notions for the Rumen Content Digesta During Transformative Digestion. 6.) Enumeratively the INputs = fibre (given forage maturity or cut) + CHOs/sugars + organic acids (silage) + protein/non-protein N sources (e. g. majoritavely the proteins, peptides, amino acids, amides, amines, nucleic acids) + fats or oils 7.) Enumeratively the OUTputs = VFAs (SCFAs) + NH4 + Organic Biomass Matter (microbial in nature) + Escape of Feed Residuals 8.) Now, the Biggest Unknown of Quantitative Modeling Using the Microbial Ecosystem of the Rumen might require "guestimates" with Quantitative Distribution Descriptions of Populations and their Subpopulations in Real Time rather than a more vague "Black Box" approach. Flash frozen pictures of samplings in time can be now illustratively enumerated subpopulationally based on their unique ribosomal signature to enumerate them via cell counting in the rumen. 9.) Specification of Ration Nutrient Components As a Given for Forage (hay, silage, grazed):: Grain (whole or pelleted) ratio and the Protein/Energy (P/E) ratio. 10.) The Overall "Conversion" from INputs to OUTputs to the Duodenum are thus: Overall Description (Qualitative) of Rumen Processing or Digestion: 1) CHO, Fats, P, NPN (including Urea-N from saliva and Rumen Wall); 2) The Cycle of Energy Bearing Nutrients Producing VFA Endproducts and ATP (currency of energy for cell metabolism) and then the INput Nutrients Broken Down and then Synthesized with ATP to Microbial Cell Biomass; 3) the Residual Feed Biomass Processed to Remove It to the Duodenum While the VFAs Exiting Through the Rumen Wall and so with NPN (NH4) via Urea-N to the Liver/Saliva and then Back to the Rumen Cavity; 4) the OUTput Comprised of Microbial Cells + Residual Feed Material and Including P + CHO, Oligosaccharides, Simple Sugars + Fats + NPN. It is predicted that AI (artificial intelligence) computing will be required to handle Data Processing (DP) in terms of Capacity or Quantity, and in Real-Time Calculations for a Real-Time Desciption for Live Streamed Processing Runs Representing Rumen Digestion With Our Rumen Model Construct. UPDATE ON D. A. FLORES' RESEARCH (2022-2026): Thanks for keeping in touch with Skye Blue SB Internet. We are located here in Port Coquitlam (POCO) BC Canada V3B 1G3. Our goals for future research focuses around (2):
1. Promote academic exposure for potential future postgraduate studies which our Principal/Owner at SB Internet is still pursuing in terms of doctoral and postdoctoral studies to follow with collaboration in lab bench-based research and/or research on the WWW or Internet (as a Google-based scholar), as he has in the past.
2. R&D opportunities and commercialization with a CRO/CDMO company either partnered with or with his own organization and for IP protection in a corporate environment with partners who demonstrate the financial backing and wishing to build with their assets with their eventual portfolios and given the options for SB Internet to purchase shares on offer in such aforementioned companies in exchange of use of SkyeBlue's exclusive ideas under their copyright with all rights reserved.
D. A. Flores' Publications on Biomolecular and Animal Science Research (2022-2026): the Rumen & Lower Gastrointestinal Tract (GIT) Digestion & Nutrition with Functional Feed Ingredients or Nutritionals. Here are our Owner's/Principal's recent progress as a Google scholar on the world-wide web, WWW, in his specialty of functional feeding with nutritionals updating its impact on the rumen stomach and the rest of the lower gastrointestinal tract (GIT) as it has appeared in the scientific literature: 1. Probiotics (non-GMO, GRO with PNA-B12 Biologics). 2. Nutraceuticals (e.g. bioactive, antioxidants): 1. Peptides (MCP, FFA, cardionetics, stress, immunomodulation), 2. Oligosaccharides (e. g. FOS, AOS, GOS, XOS, MOS, COS, POS, GA). | I I V
1. Rumen Digestion & Nutrition <---- FFA Mechanism by 'catalytic' peptides** 2. Lower Gastrointestinal Tract (GIT) | I I V
1. Neuro cognition (memory, the vagus gut-CNS axis) 2. Animal Production Yield (meat production, quality) 3. Antioxidants System (Nrf2) & Animal Health (e.g. Ileum Inflammation)
**Footnote. The functional rate Eqn. or velocity has been derived by D. A. Flores (2026) (See: DAFS Paper #5 from his DAFS journal publication, given below) and can be simplified in terms of the ff. assumptions. There is one catch that has to be taken care of in the rate Eqn. [1] describing the effect of activator peptide [A] on the phenomenon, thus, v = k * [S]2 * [Protein Polymer Elongating] * [A]. To arrive at the measurement: v = mg P/sec. from MCP fraction measurement, [S] is constant for all pools of 21 amino acid monomeric units attaching to the polymer by utilizing equimolar concentrations of each amino acid in oligopeptide form transported into the clonal microbial cells in the artificial rumen milieu and finally variated [A] or concentrations of the activator peptide added also in excess as the feed source for semi-purified protein produced by Clean Fermentation in bulk amounts. As an additional measure to investigate our assumption with [S], fractionating of the stopped sample's aliquot with its precipitation after cell disruption of protein is to analyze via HPLC chromatography profile of intracellular [S] or amino acids concentrations for the 21 pools minus remaining peptide fractions in the fraction collected.
There are preliminary in vitro experiments with our chosen microbial spp. to screen for oligopeptide candidates that occur both in the in vitro milieu and as extracted and analyzed intracellularly and tested under controlled conditions alone or together in vitro to determine their activating effect on MCP synthesis for the candidate microbial clonal culture. Finally, a chosen candidate oligopeptide [A] with maximum effect will used for the in situ experiments after FFA has been confirmed in culture.
References: Research Papers of D. A. Flores in Discoveries in Agriculture and Food Sciences (DAFS) journal, Scholar Publishing (SP), Birmingham, England, the U. K.:
THE TECHTALKS PROJECT: An announcement of sbinternet.ca production broadcasting for the TECH TALK project at BBL- Barberry House, Poco, BC Canada V3B 1G3 is made here. We will feature news items or announcements of drug discovery, nutraceutical feeding & nutritional metabolism and physiology, advances in understanding crops, livestock and their feeding & nutrition for these innovative developments at Skye Blue. E- Episode Programming: E-1 Series New Developments in Modern Cropping, Livestock and Food Manufacturing. E-2 Series New Relief with Systemic Chronic Inflammation (SCI) and Progress in Preventative Care. E-3 Series Evolution and the Novelty of Nutraceuticals in Feeds and Foods for the Diet. E-4 Series Discovery of New Therapeutic Care in the LMW-Proteome and the New Pharma Care. We believe in the future of twinning wheat processed residual FAR feedstock with modern enzyme technology and yeast supplementation with protein and with feed protected amino acids (HIS, ARG, THR, MET) with seagrasses of marine and freshwater origin for dairy (re. dairying with hi-bred cows will replace culling and even for meat production, thus movement away from and to vegan milk sources; at SkyeBlue we believes that animal dairy products will never be replaced for taste and flavour and other tactile qualities attractive for the consumer; more humane production practices for animal welfare will be in place in future for dairy production). Factory-made meat is predicted to come on more in future replacing our dependence on farm grown meat products in the diet. Systemic Chronic Inflammation (SCI) associated conditions will be described further implicating immuno balance including multiple sclerosis (MS), Alzheimers, Parkinsons, heart disease, T2Diabetes and Cancers including colon cancer, rheumatoid arthritis and osteoporosis. We believe we have new finds for both myocardial infarction (MI) recovery and rheumatoid arthritis (RA) involving the immune system and drug discovery for cures using novel protein-like polymers (PLP) involving deactivating Nrf2 factor in these diseases. Three leading nutritionals studied at SkyeBlue are fructans, PUFAs and VitD2,3. We will cover new development reported in the Press about MS advances with addressing the immune systems For digestion new finds by Skye Blue's Principal and Owner on a more comprehensive Protein Energy Theory of Rumen Microbial Digestion for MCP production positing the idea of Feed-Forward Activation (FFA), a first of its kind in the microbial ecological field for harsher and more competitive environments to explain tertiary structure 'chaperoning' with 'chased-forward' polypeptide synthases with peptides which explains the stimulation in synthesis found to be preferably for MCP as was found in the classical experiments of Baldwin, Russell and Broderick groups of researchers who pioneered the field. The Principal's discovery centers around FFA and the acceleration of rxn. velocity of either a free enzyme or standing polymerase. The application of this find is to discover technology for accelerating product whether it be proteinaceous, DNA or RNA, as major e. g. s. We will focus our discussion the new development of biosynthetic drug discovery with precursor Lanosteral(R) with which SkyeBlue has a proprietary interest for making the active form of VitD2,3-agonist and its proposed use in conditions like human Osteoporosis for preventative and maintenance care and in farm animals for Cow's Milk Fever during calving for prevention of bone loss and maintenance. (c) 2026-2059. D. A. Flores. Skye Blue Internet. Port Coquitlam, Brit. Columbia, V3B 1G3 Canada.
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Last update of this entry: September 29, 2026
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