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Our own "SkyeBlue" candidate as a Peptide-Nucleic Acid (PNA)-linker*-VitK1,2 [as Derivative Quinolines(x5)]. Proposed are applications for: Orthopharm for Agronomique & Agri-Food in Feeds, Foods, Green Biorecyclables, including Biochar, Vermiculture for C-sinking in Soil Fertility Support, and for Human Health with Preventative Therapeutics. (Quinoline=phenyl quinone methyl with additional R group derivative. We are proposing a linker from the phosphate-sugar backbone to a sugar with 5 functional connectors to 5 quinoline derivative molecules as a biologic candidate.)
*-(PO4-R12-hexose)(-quinoline5[=phenyl quinone methyl with additional R groups (long-chains)]); providing for a relatively sterically unhindered biomolecular assembly of relatively homogeneous hydrophobicity as a carrier to the covalently bound PNA (=peptide-nucleic acid complex).
This includes targetting RNA-based biologics with highly engineered active TF elements through TFE that are epigenetic interacting with commensal endogastric, in-residence probiotic n-plasmids (native plasmids) of specialized production animals, to accelerate digestive related processes amongst the strategically significant subpopulations of fibrolytic fungi, ligninophiles and those needing energy boosting from available soluble sugar digests for boosted protein synthesis ("storage", note: vs. "surrogate" or GMO coded proteins) via i) boosting synthesis and ii) boosting limiting "essential" amino acids in bacterial protein metabolism (bacterial spp. needing further investigation- viz. robustness, precision, accuracy- all factors to determine for the regulation (non-coding sequences of DNA) impacting the specific coding sequences of DNA and their "structural gene cassettes" of great interest here.
Apart from probiotic rumen digestive applications in livestock there is also the matter of cropping, in particular corn kernels for corn-based whole flour made to corn snacks as dietetic foods or functional foods, e. g. for diabetic applications, being slower release starch with fibre (which could be like lignocellulose-hemicellulose) and higher in protein which also alleviates the high sugar influx from its flour via insulin secretion from amino acids influx (unless there is considerable insulin resistance as a given in their condition). Apparently the pericarp of the kernel or outer shell can be possibly manipulated for fibre which should be nearer the composition of the inner membrane apposed next to the pericarp. Hopefully, this is more soluble fibre and effective for digesting slower-releasing starch for glucose. It has to be studied whether there are gas-exchange related processes and photosynthetic-related processes at the pericarp's level to service grain's growth and development and also to answer the question as to the stage of growth and development for the desposition of fibre based on the cell wall on top of the endosperm and germ with the germplasm.
There is also the need to expand this application towards functional feeding with large ruminants for beef and also dairy to avoid rumen and metabolic acidosis and stress and optimally deliver protein flows to the intestines for digestion for livestock meat and milk.
Author Bio. The author in 1988 proposed in his exclusive Literature Survey and accompanying peer-reviewed mini-survey or review with the leading J. Biotechnol. at the Uni. in NSW, Australia (Sydney) during graduate studies surveying possible strategies by using byproduct class of feeds used by the livestock husbandry industry, their endogastric manipulation, mainly plasmid-based, together with byproducts of good quality (conventional feeds are considered of v. good to excellent depending on further modification and processing) what are referred to in the feed industry as: i) energy concentrates [supplements to basal ration to boost nutritive value (N. V.)] and ii) protein concentrates [supplements to basal ration to boost protein supply and ration nutritive value (N.V.)]. The author would like to comment to the reader that technology has advanced recently, remarkably, using the previously described non-GMO technology using RNA-based gene silencing also predicted to make headway in Cancer research and other areas in Medicine not just Agri-Food, Energy and Biorecyclables or materials.
Let Us know what you think!
Our original reference, one only of its kind is found here (CLICK): https://www.sciencedirect.com/science/article/abs/pii/0168165689900321#:~:text=Journal%20of%20Biotechnology%2C%2010%20%281989%29%2095%20-%20112,microbial%20biomass%20component%20from%20feeding%20low%20quality-based%20diets.
SKYEVIEW: Recent findings by silage research and RE Muck et al. (2018) leads us to the ff. conclusive statements with silage care or making. It is widely recognized that Clostridia, the so-called other side of silage-making, is affected by two factors of Aw (water activity) and lowered pH (=3.8, low end). Their recent review uncovered possible use of direct biologicals as a feasible route against Clostridia to inhibit in silage with alternative biologicals such as enzymes that indirectly work to improve sugars availability for fermentation by favourable LAB bacteria (see: DA Flores, 1991), apart from various homo- and heterofermentative LAB applied to the ensilage-making during silo filling. Remember there are two stages testing utilization after pretreatment of ensilage use: 1) profiling via ensiling parameters in silage material and 2) animal productivity from feeding trials (e. g. Nutritive Value, N.V.).
SKYEVIEW: The funding story regarding running a GRO-led horticultural facility of a pilot plant for starting up industry is that Ottawa and Victoria can provide Canadian start-up funds for innovation and funding support regards the aspects of business support facility building or construction, technology support regards processing feedstocks and endproducts with the attendant appliances for vertical aquaponics, also hindging on their commercial availability with sourcing from Canada, United States and Europe (including the U.K.), techniques arrived at by research for aquatic botanicals (e. g. marine seagrasses) and DNA genomics and molecular biology and biochemistry of plants informational databasing using this information for techniques and their technology commercially, and finally research and development for establishing components of the pilot plant: admin./living quarters (e. g. eating, lockers, washrooms), prac room for instructional training and presentations/meetings, machine room utilities, control room for analyticals and finally the critical production area of the pilot plant and with requisite storage for processing inputs and packaging production outputs. The larger picture of Canadian government funding is to manage the ff.: continued innovation, science and economic development in Canada, continued fueling of movement in western economic diversification for not only production but also job creation and economic development and finally answering to the core issues of agriculture and agri-food in Canada, i. e. Land Food System (LFS) strategic development and its continuing sustainability.
SKYEVIEW: A GRO-led study for research is being proposed for the DOE-JGI in the U.S. Government regarding "green" chemistry for processing biomass from lignocellulosic feedstock with fungal action including yeasts for both feed and SCP + FAA feeding with livestock classes as in swine, poultry and fish, not to mention a "SkyeBlue" priority goal for making so-called "yeast" bagasse. Also for the IAFBC of Western Canada regards fisheries and ecosystems genomic technologies including current salmon infestation in open net fisheries in the Pacific in regards to Piscine rheovirus and sea lice. SkyeBlue might involved itself in anti-viral/host immunity mechanisms using GRO biologics (see: UBC Point Grey campus, Vancouver Canada) and other biologic or chemical anti-viral strategies. And as for agronomic cropping with genomic innovations reduing environmental impact from crops are regulating: photosynthetic mechanisms, auxins (question: but regards what issues developmentally for both plant health and productivity and C-sinking with CO2 in the atmosphere and how regulatory modifications with the former (2) lead to alteration of the nutrient/energy inputs vs the productive biomass outputs of the plant system, an equation that is tantalizing.
(c) SKYE BLUE INTERNET. PORT COQUITLAM, B. C. V3B 1G3 CANADA.
Last update of this entry: October 30, 2023