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registry of biomedical companies

  October 05, 2023
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Registry of biomedical companies:

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(GRO)-Genomics of Canada

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Port Coquitlam Brit. Columbia
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                         Our own "SkyeBlue" candidate as a Peptide-Nucleic Acid (PNA)-linker*-VitK1,2 [as Derivative Quinolines(x5)]. Proposed are applications for:  Orthopharm for Agronomique & Agri-Food in Feeds, Foods, Green Biorecyclables, including Biochar, Vermiculture for C-sinking in Soil Fertility Support, and for Human Health with Preventative Therapeutics.  (Quinoline=phenyl quinone methyl with additional R group derivative. We are proposing a linker from the phosphate-sugar backbone to a sugar with 5 functional connectors to 5 quinoline derivative molecules as a biologic candidate.)                  
*-(PO4-R12-hexose)(-quinoline5[=phenyl quinone methyl with additional R groups (long-chains)]); providing for a relatively sterically unhindered biomolecular assembly of relatively homogeneous hydrophobicity as a carrier to the covalently bound PNA (=peptide-nucleic acid complex). 
                        This includes targetting RNA-based biologics with highly engineered active TF elements through TFE that are epigenetic interacting with commensal endogastric, in-residence probiotic n-plasmids (native plasmids) of specialized production animals, to accelerate digestive related processes amongst the strategically significant subpopulations of fibrolytic fungi, ligninophiles and those needing energy boosting from available soluble sugar digests for boosted protein synthesis ("storage", note: vs. "surrogate" or GMO coded proteins) via i) boosting synthesis and ii) boosting limiting "essential" amino acids in bacterial protein metabolism (bacterial spp. needing further investigation- viz. robustness, precision, accuracy- all factors to determine for the regulation (non-coding sequences of DNA) impacting the specific coding sequences of DNA and their "structural gene cassettes" of great interest here.
                       Apart from probiotic rumen digestive applications in livestock there is also the matter of cropping, in particular corn kernels for corn-based whole flour made to corn snacks as dietetic foods or functional foods, e. g. for diabetic applications, being slower release starch with fibre (which could be like lignocellulose-hemicellulose) and higher in protein which also alleviates the high sugar influx from its flour via insulin secretion from amino acids influx (unless there is considerable insulin resistance as a given in their condition).  Apparently the pericarp of the kernel or outer shell can be possibly manipulated for fibre which should be nearer the composition of the inner membrane apposed next to the pericarp.  Hopefully, this is more soluble fibre and effective for digesting slower-releasing starch for glucose. It has to be studied whether there are gas-exchange related processes and photosynthetic-related processes at the pericarp's level to service grain's growth and development and also to answer the question as to the stage of growth and development for the desposition of fibre based on the cell wall on top of the endosperm and germ with the germplasm.
                        There is also the need to expand this application towards functional feeding with large ruminants for beef and also dairy to avoid rumen and metabolic acidosis and stress and optimally deliver protein flows to the intestines for digestion for livestock meat and milk. 
Author Bio.  The author in 1988 proposed in his exclusive Literature Survey and accompanying peer-reviewed mini-survey or review with the leading J. Biotechnol. at the Uni. in NSW, Australia (Sydney) during graduate studies surveying possible strategies by using byproduct class of feeds used by the livestock husbandry industry, their endogastric manipulation, mainly plasmid-based, together with byproducts of good quality (conventional feeds are considered of v. good to excellent depending on further modification and processing) what are referred to in the feed industry as: i) energy concentrates [supplements to basal ration to boost nutritive value (N. V.)] and ii) protein concentrates [supplements to basal ration to boost protein supply and ration nutritive value (N.V.)]. The author would like to comment to the reader that technology has advanced recently, remarkably, using the previously described non-GMO technology using RNA-based gene silencing also predicted to make headway in Cancer research and other areas in Medicine not just Agri-Food, Energy and Biorecyclables or materials.
Let Us know what you think!
Our original reference, one only of its kind is found here (CLICK): https://www.sciencedirect.com/science/article/abs/pii/0168165689900321#:~:text=Journal%20of%20Biotechnology%2C%2010%20%281989%29%2095%20-%20112,microbial%20biomass%20component%20from%20feeding%20low%20quality-based%20diets.

SKYEVIEW: Recent findings by silage research and RE Muck et al. (2018) leads us to the ff. conclusive statements with silage care or making. It is widely recognized that Clostridia, the so-called other side of silage-making, is affected by two factors of Aw (water activity) and lowered pH (=3.8, low end). Their recent review uncovered possible use of direct biologicals as a feasible route against Clostridia to inhibit in silage with alternative biologicals such as enzymes that indirectly work to improve sugars availability for fermentation by favourable LAB bacteria (see: DA Flores, 1991), apart from various homo- and heterofermentative LAB applied to the ensilage-making during silo filling. Remember there are two stages testing utilization after pretreatment of ensilage use: 1) profiling via ensiling parameters in silage material and 2) animal productivity from feeding trials (e. g. Nutritive Value, N.V.). 

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