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registry of biomedical companies

  June 03, 2023
promoting the transfer of scientific know-how between industry and academia
Registry of biomedical companies:

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Antonello-Tomaso Rancheros of Canada

1440 Barberry Dr.
Port Coquitlam
Toll free: +011-604-941-9022 (help line)

Phone: 16049458408
Fax: +011-604-941-9022 (FAX line)
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We are part of organizing an alliance in Negros Province, the Republic of the Philippines (RP), with an interest in influencing developments within the Negros Island region, particularly in Palinpinon, Bais/Tanjay, and in the NDA Region 7 - Central Visayas: Negros, Bohol, Cebu and Siquijor. The NDA - National Dairy Authority in the Philippines, is perceived to encourage dairying as a key product of livestock raising given the marketplace, demographics and consumer preferences including using caramilk as one outlet and conventionalized dairy cattle raising using common AIBPs such as with surplus urea-N and unrefined or raw sugarcane/molasses and sugarcane tops (SCT) that is either untreated, 'bio-siled' [including here more advanced approaches (viz. quite intensive use of biologicals)], or 'chemo-siled' (sulfuric acid/urea-ammonium) sugarcane tops (SCT) - and/or with bagasse via solid-substrate fermentation (SSF) processed or 'yeast bagasse' with fibrolysis and added fungal SCP. In both cases a solution of 'as is' molasses is sprayed to increase the energy density for higher producers and the 'proteinogenic potential' of the feed.

There is currently now a burden on scientific expertise for further R&D to produce XL Grow varieties to test economies of scale with both pharma, energy and fodders, including use of 'closed' biosafe facilities avoiding pollination by GMO plant varieties-  e. g. through techniques utilizing protoplasmic fusion and PNA-Auxin/ARF. We strongly encourage exploration by recruitment of local (e. g. UBC, Vancouver Canada), multi-national botanists (e. g. Indian botanists and those from China), and plant biotechnologists, and/or crop agronomists from schools in our region in the West in Canada. 

The particular issue of whether the Palinpinon project used to be true as planned was whether a 'closed' biosafe facility could be built by Filipino expertise using seagrass secondary alkaloids as anti-pollinator blockers in solution without escape sans protoplast fusion technology and experimentation. It is believed that further study of known biosafe laboratory requisite GMPs will answer the issues involved.

Open ponds culture is also an option but currently scarce land area or resources would probably make this prohibitive in cost (e. g. lease and taxation) for non-GMO varieties. What technologies will be required to produce the varieties and the undue needed safeguards defining what is biosafe would make it further prohibitive.

Agri-food with our functional food product lines (e. g. see: Josephus & Sons Foods Canada) will be an area for expansion including texturized fat-oil mixtures such as the L'Oleo (R) trade product and L'Oligo (R) smoothie nutritional supplement of complex carbohydrates (including WSC) and of a gourmet Pepper-Peanut sauce marinade or ketchup for meats, fish like salmon, eggs, as a pasta/noodle sauce, and as a salad dressing are all being gradually converted to IP-protected  product ideas for eventual marketing (commercialization).  


A. Agropur-Co-op:


     (a) Hi-NEAA/Hi-HIS Yeast Cultured Supplements. These are e. g. s. to be amalgamated with cornmeal-based chicken and piggery diets with growth promoters as such and deemed organic. These will provide 'a niche' under current standards for both banned use of antibiotic and hormonal growth promoters or factors in animal feeding. 

     (b) PNA-B12 RNA-based Technology (non-GMO GRO) for ensiling and rumen/digestive management.

     (c) Alkaloid biosafe-contained requisite GEdited (GM or GMO) Pharma varieties to prevent spawning, i. e. pollination outside the 'closed' facility.

    (d) Sugarcane Tops (SCT) farming for ranching as silage will be employed for year-round feeding both grass from pasture and SCT silage from sugarmilling using an auger in a two-vat conformation with milling or fine-chopping to take place first, then mixing at auger with H2SO4 (aq) to delignify and add sulfur (S) to improve fibre digestibility and then neutralization in a second vat with urea solution (aq) again at auger to add nitrogen (N) (important: well-ventilated conditions) to improve also digestibility of forage, both for microbial digestion.  

Local 'Cara-Ranching' for dairy and meat (e. g. in the Town of Ayungon, Negros Oriental ) subject to employing supplies of oversown and managed lush pasture for high-quality green fibrous source with lower-quality feeds together only for these higher efficiency digesting animals given advances yet to be discovered in centre of research and learning like UPLB for the NDA Region 7 or Central Visayas region with ensilage of the common material of sugarcane tops or SCT, as it popularly known in places like Mauritius seasonally harvested but made available throughout the year for feeding. 


B. Micropur-Co-op:


Re-uptake and Sequestration by Active Transport Processing of K+ and (PO4) 2- Conservation in Soil Microbes and Root Calli of Plants. Research is required to establish methods of soils enrichment with fallow using intercalated plant hedgerows with ploughing back into soils together with soil microbe cultures subsisting there.

This would represent a breakthrough in organic farming practices using microbial interventives practiced in the Philippines versus chemical intensive inputs.


C. Dairypur-Co-op:


[1] Medicinal GMO Milk Cows via gene editing (GE) or better sublingual PNA-B12 to accelerate milk food protein synthesis near the udder of cows, fed all-year round silage from emerging aquatic botanical spp. like water hyacinth and duckweed & histidine functional amino acids supplements such as proposed from yeast from fine-milled bagasse. 

[2] Low-cholesterol GMO Layers for eggs (ducks, quails and chickens) modified genetically for the cholesterol esterase gene in fowl, and fed functional amino acids (HIS, ARG, LEU, MET and LYS- these are all yet to be tested as candi-      dates for limiting amino acids.


D. Palinpinon-Co-op:

    (Palinpinon/La Carlota-Vancouver-area subsidiaries) 

[1] Bio-Agrosil Feeds (BASF) Laboratories (Palinpinon) - Growers, Microbiology, Feed Formulation. Proposing to further investigate recent finds of (1) HQ long fires for improving protein digestion as (2) Avicel (R) or lignin in poultry diets to improve protein digestion. Various approaches: (1) down-regulation by GM of proteases in grain (but where in the grain and it's distribution is yet to be determined), (2) heat denaturation by extrusion and feeding, (3) Avicel (R) or purified lignin which is hypothesized to denature protein to optimize availability for digestion, and finally (4) our yeast bagasse vs widely used and available bagasse-based feed can also be further studied using Avicel (R) with heat extrusion and pelleting.

[2] Polera Growers Co. (Palinpinon) - Growers, Tree Farming, Aquafarming, and Energy Generation from Biofuels. There is a movement in the biorenewables industry to twin both lignase-III systems to mineralize lignin to CH4 and ferment the cellulose fractions with fungi in tandem with Methanobrevibacter spp. Also CH4 to formate is to be shipped elsewhere for IBPN manufacturing to various infrastructural and capital products and consumables. The feasibility of this study for industry development will proceed, as we speak, with establishment where pulp mfging. is abundant and where environmental protection laws apply for the handling of cynanide-benzene solution as a chemical. Most likely in remote areas around the globe and where it is v. cold (perhaps for e. g. Siberia and the near-Arctic) for quenching deadly cyanide gas [HCN (g)] escape using a scrambled heli-jet crew or team to spray using our "Clean-O" the chemical leak(s) if they occur which can be immediately lethal to wildlife.

[3] Polera Feeds Co. (Palinpinon-area & Vancouver-area) - a subsidiary in Vancouver, B.C. in Feeds for Cara-Ranching, Piglets & Finishing, Fisheries, Goatary Dairying with Specialties in Functional AA Supplementation. Like the unique wheat based pasta, polenta, polera refers to the Indian golden yellow genetically edited (GE) (CRISPR/Cas9)/back-crossed & selected rice variety that we plan to develop in the Philippines and process via importation into the Vancouver market for export to China and the rest of Asia including the Philippines and India. Other varieties of pasta from rice and wheat, and starch from root-based crops with either wheat or rice may be marketed eventually in the African marketplace and world-wide health food market. These are novel, original and imaginative to the consuming marketplace.

A feed co. we are planning on at "SkyeBlue" is that developed from the Palinpinon ranchero area using greens from young coconut midrif fronds duly harvested and sugarcane tops (SCT) that is derinded from "tubo" and fine-milled to fine mm particle size (hopefully at this time field solar powered choppers in the tropics can be deployed), then processed by treatment with lignocellulases and if need be processed out of any deleterious (toxicity, palatability) substances yet to be tested and feeding trials started for intake (%BW) with dairy and beef cattle to eventually be paired with a fibre, hi-energy and protein-dense supplement from fine-milled "Yeast Bagasse" as the other half of the ration.

There are three types of buffalo breeds to test in ranchero-style rearing at Palinpinon NegOr Philippines, Murrah, Surti and Nili-ravi and their crossbred varieties.     

[4] Genus Mariner Labs (see: Our 'colourful' website under 'Genus' and 'wixsite.com') (Palinpinon) - (see: site) (To be ceded in partnership as collabs in future.): (1) Priority is first on primary industry of growing submerged 'lawns' of seagrass for fodder eventually meant for locally produced hi-end producing dairy animal livestock, year-round and that are labelled as 'grass-fed' and treated GMO-free milk food products (MFP); (2) producing XL-GMO varieties of seagrass for a biosafe facility for hi-sugar complex carbohydrates for the healthfood supplement market - or even just conventional non-GMO hi-producing varieties; (3) hi-quality (HQ) biofuel feedstock in cellulose-fermenting bioethanol plants which currently use bagasse only as a byproduct of the sugarmilling industry on the Island; and (4) capital-intensive agropharming production with more sophisticated downstream processing vs. current fermentor vessel technology with microbial host and rec-DNA technology.

[5] CBDNet (Central Business District Network)(HOME | Cbdnetwork (dannflores5.wixsite.com ), Skye Blue Association (see our 'colourful' website at: http://americangryphon5.wixsite.com/americangryphon5) (Palinpinon) - GMC Car parts & distribution (import/export), we predict, will become available to our concept car or cab vehicles subject to further local investment in the Kabangkalan area by such American motoring concerns in concept mini cars and van-a-wagon formats.

     The rumour mill abounds with the latest possible news and developments regards the RP (Philippines) position and its potential investors: (1) the continued commitment of American and/or Canadian cos. to setup plant factories and parts distribution (import/export) to places like Cambodia and Southern China, for e. g., from a site like Kambangkalan Negros Occidental, RP (Philippines) where infrastruc-ture development seems to suggest strongly a possible investment by American firms; however, if this falls through, vis-a-vis foreign policy relations in the years ahead with the U. S. A., China instead might be made a stopping-off point from the socio-culturally-fit region in the South for such vehicular or commuter traffic sent to the RP (Philippines); (2) there is also the option from an Australian-German cooperative consortium or merger to develop an adapted vehicle "on the ground" for the RP (Philippines) and field it for export to or local manufacturing in the country. Both the prestigious carmaker BMW and the oft well-known Australian carmaker Holden (R) rings a bell to all of us in the West.

[6] Dairy Processing Facility annexed to Water Buffalo Ranching for Caramilk and Carabeef. We are planning to process dairy milk like caramilk into ricotta and creamery like products in conjunction with Josephus & Sons Foods (see this website under biomedical cos.) for marketing in Australasia and even Europe (e. g. Easter Europe) as a Eurasian dairy milk food product.  Let us know by writing in of any updates or news on the investment front that we know of. Thank you. 



SKYEVIEW: Known to the author are (4) modes for peptide technology delivery in rumen protein digestion: food-grade ion-exchange resins, time-release capsulation (e. g. through the gastric chamber and further downstream, microencapsulization of omega-3 fatty acids and vegan and meat-based peptides as in our proprietary Elastane(R) from x-linked elastin and pellet extrusion of peptides from feed peptide technology (for e. g. from clean vegetable or meat fermentation and their "encapsulization" in heat-damaged extruded grain material between carbohydrate sugars and protein), all being feed or food-grade. This was recently discovered or recognized by SkyeBlue with our work in functional feeding and needs urgent investigation and proprietarization as a feed manufacturing concern using advanced enzyme technology.

SKYEVIEW: The growing co-op movement will finally gain impetus from loans available from banques and stock investments and from locals engaged in share buying becoming more popular as confidence grows in these types of technological industrial offerings. Industrialization stemming from the co-op movement will be perceived tantamount to attain a higher standard of living from higher incomes obtained from better paying jobs and production of higher value-added goods and services. From "rice paddies'" humble beginnings three technological breakthrough through Indigenous human resources development plus licensing investments using technology transfer for hi-tech farming will emerge: 1) XL-Grow varieties, 2) Pharma used with GEditing with traits using CRISPR/Cas9 technology and 3) Economically produced (viz. land lease and taxation) XL-Grow varieties as bioethanol feedstock in ligno-cellulose-fermenting plants that currently utilize bagasse from local sugarmills.

SKYEVIEW: Tropical ensilage effectiveness has always been speculated on due to elevated temperatures, high sugar content in SCT, the steep need to improve protein retention in biomass for hi-producing cattle and dairy producers, similar moisture content of fresh forage as with grasses and legumes. The role of accelerating the acidification of silage with direct applied biologics like PNA-B12 conjugated gene silencing mRNA-based nano-scale technology is probably prognosticated to be cost-effective as a prebiotic approach for higher demanding hi-bred producing livestock. 

SKYEVIEW: Despite rumours the new fishpond culture is taking hold in the PR we view the issue as another type of fishpond, from that perspective, given the practice of aquaponics wherein fish stocks or their fry are grown further with inputs of fish meal and the fish in turn fertilize important aquatic plant stock like our proposed seagrass and duckweed (perhaps not water hyacinthe), the latter for ducks, and former for the fish. Another issue is whether imported varieties or species, e. g. from the Southern and Eastern coasts of India and Sri Lanka, can be used internally in the Philippines but just in perimeterized surroundings amongst fishpond culturists without escape, especially if the species is ecologically invasive or aggressive to the natural flora in the surrounding sea. We still hold that Philippine policy should carry through with government benefits for land reform and land lease with taxation for the benefit of the tax payer base including subsidies and other infrastructural helps. What about ranching, mixed farming situation and outright sale of fodders for feedstock. The market could still be developed further including lucrative energy contracts compared to sugarcane bagasse that has to be heavily treated with biologicals (enzymes, fungi) and/or chemicals (acids like H2SO4 and bases like NaOH). One wonders if there is more energy from oil on the horizon for Filipino alikes in the near future and energy inputs become commonplace for industrialization- the hope for tomorrow for the Filipino.

SKYEVIEW: There is 'news on the wire' in Negros province that efforts are being made to foray into the other side of the two, that is, Negros Oriental province, where there is significant investment potential for further market studies to provide jobs to the grass roots labour base of the province through both direct philanthropy with their foundations and local banques, i. e. co-op industries including: agri-food industries for import-export, food services (e. g. GMP is a major issue using clean food, water, and land practices with modern equipment and tools or implements), transport and tourism, e. g. International airports of which three are planned for the region and in the Philippines for freight of both freight forwarding, local commodities for export from Negros Oriental industry and nascent industries for entertainment and travel or recreation. In fact, there is a rumour that the likes, once staged for local industry, of SONY and Disney World Entertainment will buy considerable tracts of land in the Southern section for hotels, even beachfront property and an e-World entertainment centre for rides, venues or shows and including 3-D tele-cinema, concessions including gaming (we believe that legalized gambling to a limited extent as can be sanctioned in the Province depending on legislation and other security commissions regulation) and the major draw card is to be e-gaming & concession entertainment, especially for Youth, which is found to be true in the Philippine Islands. What this will do to the local Makati stock market is open to question and will be further monitored by regulatory government commission.


(c) D. A. Flores. SKYE BLUE INTERNET. Port Coquitlam. BC. Canada V3B 1G3. 

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