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RNA interference (RNAi) has become the standard tool for sequence-specific gene knockdown in laboratory research. After initial hype and the hope that RNAi would develop into a potent novel strategy for the therapy of many diseases, it became clear that several problems associated with the technology remain unsolved. One of these challenges is off-target effects, i.e. most siRNAs not only target their complementary on-target gene but also deregulate an unknown number of off-target genes. These off-target effects are sequence-specific and intrinsic to each siRNA. Even though some progress was made to reduce off-target effects, no RNAi reagent so far provides a satisfactory protection against off-target effects.
Our next-generation RNAi reagents, called siPOOLs, are complex pools of 30 selected siRNAs against the target gene. Thus,
- siPOOLs are sufficiently complex to reliably dilute the off-target effects specific to each individual siRNA molecule below detection limit, and
- siPOOLs are a defined composition of siRNAs, leading to highly efficient and reliable gene knockdown results and clear phenotypic data.
Last update of this entry: March 16, 2015
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