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registry of biomedical companies

 
  September 30, 2016
promoting the transfer of scientific know-how between industry and academia
 
 
Registry of biomedical companies:

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siTools Biotech GmbH

Lochhamer Str. 29a
82152 Planegg
Germany

Phone: +49 89 4431 2453
Fax: +49 89 8955 7281
E-Mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

Description:

RNA interference (RNAi) has become the standard tool for sequence-specific gene knockdown in laboratory research. After initial hype and the hope that RNAi would develop into a potent novel strategy for the therapy of many diseases, it became clear that several problems associated with the technology remain unsolved. One of these challenges is off-target effects, i.e. most siRNAs not only target their complementary on-target gene but also deregulate an unknown number of off-target genes. These off-target effects are sequence-specific and intrinsic to each siRNA. Even though some progress was made to reduce off-target effects, no RNAi reagent so far provides a satisfactory protection against off-target effects.

Our next-generation RNAi reagents, called siPOOLs, are complex pools of 30 selected siRNAs against the target gene. Thus, 
- siPOOLs are sufficiently complex to reliably dilute the off-target effects specific to each individual siRNA molecule below detection limit, and
- siPOOLs are a defined composition of siRNAs, leading to highly efficient and reliable gene knockdown results and clear phenotypic data.



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Last update of this entry: March 16, 2015

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