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registry of biomedical companies

 
  November 14, 2018
promoting the transfer of scientific know-how between industry and academia
 
 
Registry of biomedical companies:

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Vybion, Inc.

584 Oak St
Monterey, CA 93940
United States of America, California

Phone: 607-227-2502

Description:

Vybion is a virtual company that uses proprietary technologies develop therapeutic Intrabodies (intracellular scFvs) for unmet needs.  INT41 is a disease modifying Intrabody delivered as a Gene Therapy (rAAV) for the treatment of Huntington's disease (HD), a lethal neurodegenerative disease.  INT41 prevents oligomer and aggregate formation of mutant Huntingtin protein and gene dysregulation by targeting the toxic poyglutamine conaining N-terminal fragment of the huntingtin protein for degredation in the cytoplasm thereby reducing levels in the nucleus where gene dysregulation and perinuclear aggregates occur. Both cell-based and animal models have demonstrated efficacy and mechanism of action.  INT41 indications also include Spinocerebellar Ataxias, Spinal Muscular Atrophy and Tau pathologies. 

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Last update of this entry: August 28, 2018

   
 
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