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Registry of biomedical companies:
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584 Oak St
Monterey, CA 93940
United States of America, California
Phone: 607-227-2502
Please notice: This entry hasn't been updated by the submitting company for more than 2 years. It could be possible that this company doesn't longer exists.
Description:
Vybion is a virtual company that uses proprietary technologies develop therapeutic Intrabodies (intracellular scFvs) for unmet needs. INT41 is a disease modifying Intrabody delivered as a Gene Therapy (rAAV) for the treatment of Huntington's disease (HD), a lethal neurodegenerative disease. INT41 prevents oligomer and aggregate formation of mutant Huntingtin protein and gene dysregulation by targeting the toxic poyglutamine conaining N-terminal fragment of the huntingtin protein for degredation in the cytoplasm thereby reducing levels in the nucleus where gene dysregulation and perinuclear aggregates occur. Both cell-based and animal models have demonstrated efficacy and mechanism of action. INT41 indications also include Spinocerebellar Ataxias, Spinal Muscular Atrophy and Tau pathologies.
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- Biopharma
- - General
- Pharmaceutical
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Last update of this entry: May 05, 2020
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