TDT and simple association for cohort analyses

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Topic: TDT and simple association for cohort analyses

cjp1002
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posted 01-04-2008 05:25 PM

I have just SNP genotyped a cohort and our collaborator has completed the statistical analyses using both simple association models and quantitative TDT to look for association with phenotype.

Now testing for simple association is generally thought to have more statistical power than using TDT (due to the large number of DNA trios that are not informative for TDT). However we have several statistically significant associations found using TDT that were not evident by simple association.

Any ideas why this may have occurred?

Thanks,
cjp1002

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