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 DIAGnostics - Clinical Research (professional requests)
 Silver Russel Syndrome
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| Author | Topic: Silver Russel Syndrome |
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Saqib Mahmood Member |
posted 07-02-2000 05:21 AM
   
Dear Colleagues, Would you please inform me whether there is a marker (biochemical, Cytogenetics, DNA) for the definite diagnosis of Silver Russel Syndrome. What are the chances of a couple having their first child suffering from this syndrome to have similar children in the subseq0uent pregnacies. Best regards Dr Saqib Mahmood IP: 203.135.14.196 |
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zafar nawaz Member |
posted 03-02-2006 04:40 PM
Russell-Silver syndrome has multiple etiologies. Most commonly, it occurs in a single individual in a family. Known etiologies include maternal uniparental disomy for chromosome 7 and autosomal dominant or autosomal recessive inheritance. When a proband has RSS as the result of maternal uniparental disomy for chromosome 7, both parents are predicted to be unaffected, the risk to the sibs is not increased over that of the general population, and the risk to offspring is probably low. Prenatal diagnosis for Russell-Silver syndrome is usually not possible. As most occurrences of Russell-Silver are in a single individual in a family, most pregnancies are not identified to be at increased risk for RSS. if you need more information please visit this website and you will find a review article. http://www.genetests.org/ IP: 170.140.230.131 |
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