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Author Topic:   Silver Russel Syndrome
Saqib Mahmood
posted 07-02-2000 05:21 AM     Click Here to See the Profile for Saqib Mahmood   Click Here to Email Saqib Mahmood     Edit/Delete Message Reply w/Quote
Dear Colleagues,

Would you please inform me whether there is a marker (biochemical, Cytogenetics, DNA) for the definite diagnosis of Silver Russel Syndrome.

What are the chances of a couple having their first child suffering from this syndrome to have similar children in the subseq0uent pregnacies.

Best regards

Dr Saqib Mahmood
Department of Biogentics
The Children's Hospital &
The Institute of Child Health
Ferozepur Road
Lahore - Pakistan.


zafar nawaz
posted 03-02-2006 04:40 PM     Click Here to See the Profile for zafar nawaz   Click Here to Email zafar nawaz     Edit/Delete Message Reply w/Quote
Russell-Silver syndrome has multiple etiologies. Most commonly, it occurs in a single individual in a family. Known etiologies include maternal uniparental disomy for chromosome 7 and autosomal dominant or autosomal recessive inheritance. When a proband has RSS as the result of maternal uniparental disomy for chromosome 7, both parents are predicted to be unaffected, the risk to the sibs is not increased over that of the general population, and the risk to offspring is probably low. Prenatal diagnosis for Russell-Silver syndrome is usually not possible. As most occurrences of Russell-Silver are in a single individual in a family, most pregnancies are not identified to be at increased risk for RSS. if you need more information please visit this website and you will find a review article. http://www.genetests.org/


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