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Author Topic:   Different peptide services offered Online
posted 04-05-2015 10:59 AM     Click Here to See the Profile for catalogpeptide01   Click Here to Email catalogpeptide01     Edit/Delete Message Reply w/Quote
Custom Peptide Synthesis is carried out in order to get research grade or bulk API polypeptides. The notable thing about the custom peptide synthesis is that it can also be modified during the process of synthesis for specific used like diagnostic and therapeutic purposes. In the case of liquid phase custom peptide synthesis (LPPS) one shall remember that it is used only for short dipeptide synthesis, while large scale solid phase custom peptide synthesis (SPPS) is most suitable for preparing biologically active peptide which includes long, difficult and hydrophobic peptides.
The question arises that how peptides can be synthesized? It can be synthesized from immunograde purity (> 70 %, sufficient for generating or testing antibodies) to higher purity (+ 95 %, required in enzymological and biological activity studies and other applications). Bio-Synthesis is one of the most reputable institutions providing custom peptide synthesis where it can be synthesized up to 200 amino acids. Longer peptides can be produced through recombinant peptide technology.
Bi-Synthesis also offers different types of services to its clients mainly:
• Free peptide consultation and design services
• Aliquoting service
• Mass spec analysis and HPLC chromatogram to confirm purity and identity
• Delivered as lyophilized powder and packaged under dry argon gas to minimize oxidation
Bio-Synthesis experience in the peptide synthesis services is as old as three decades, it offers competitive prices, world-class support and fast delivery time. Bio-Synthesis is also compliant with TQM (Total Quality Management) to make it sure that each peptide is synthesized with strict quality standard.
Since 1984, Bio-Synthesis has been offering Peptide Synthesis services to the life science research community and drug manufacturers. The company offers wide and a complete range of premium quality peptide products ranging from bulk API polypeptides to high throughput library peptides and peptide array preparation. It also offers the services of large number of peptide modifications and also peptide synthesis for diagnostic, therapeutic and clinical applications. Bio-Synthesis specializes in both, liquid phase and solid phase fmoc peptide synthesis chemistry. There is a long standing record in preparing biologically active polypeptides including long, complex and hydrophobic peptides synthesized on different given specifications.
Peptide conjugation service is one of the many services that Bio-synthesis offers to its clients. The peptide conjugation is offered using a variety of immunogenic carrier proteins, enzymes, toxins, drugs or Oligonucleotides for use as an immunogen or for affinity purification. A number of immunogenic carrier proteins like Keyhole Limpet Hemocyanin (KLH), Diphtheria Toxoid have been used in conjugation with many peptide chemistries. We also offer coupling of peptides to various types of gel to create an immunosorbent for positive or negative selection of macromolecular binding entries such as antibodies.

Since target delivery involves the use of a biological vector that is covalently bound to a therapeutic agent such as drugs, biologic, toxins etc.
Peptide-drug conjugation contains a peptide delivery vector, a therapeutic warhead and a linker that covalently attaches the vector and the warhead. One of the most notable key features of the peptide drug conjugation is that peptide delivery vectors are often short peptides with less than 40 amino acids. For example, cell-penetrating peptides (CPPs) such as Tat CPP peptides derived from the HIV transcriptional activator protein.

For more Information visit on- Peptide Synthesis

As a pioneer in oligonucleotide synthesis, Bio-Synthesis has been pursuing the development of new oligonucleotide-based techniques that can produce compounds with superior binding affinity and chemical/biological stability. As such, Bio-Synthesis has introduced a third generation of nucleic acid analogs, Bridged Nucleic Acid (BNA).  These are RNA analogues which can be synthesized and spiked with DNA or RNA in order to modify the formation of nucleic acid helices. 


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