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Custom Peptide Synthesis
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|Author||Topic: Custom Peptide Synthesis|
posted 04-05-2015 10:45 AM
Peptide is becoming more in demand since natural protein is limited for research and clinical purposes. Moreover, for diagnostic and drug discoveries the length of peptide is a concern among the scientists. To meet specific demands a lot of peptide synthesis service providers are offering custom peptide synthesis for you. Bio-synthesis, one of the leading service providers of peptide synthesis is offering Custom Peptides Synthesis which is performed in order to produce research-grade or bulk API polypeptides. These peptides can also be modified during synthesis for specific diagnostic and therapeutic applications. Liquid Phase Custom Peptide Synthesis (LPPS) is used for very short dipeptide synthesis, while large scale Solid Phase Custom Peptide Synthesis (SPPS) is suited for preparing biologically active peptides including long, difficult and hydrophobic peptides.
The best thing custom peptide synthesis from Bio-Synthesis is that it offers competitive prices, world-class support and fast delivery time. Bio-Synthesis is compliant with TQM (Total Quality Management) to ensure that each peptide is synthesized to strict quality standard.
How peptide is synthesized?
Peptides can be synthesized from immune grade purity (> 70 %, sufficient for generating or testing antibodies) to higher purity (+ 95 %, required in enzymological and biological activity studies and other applications). Peptides can be synthesized up to 200 amino acids. Longer peptides can be made through recombinant peptide technology.
• Free peptide consultation and design services
• Aliquoting service
• Mass spec analysis and HPLC chromatogram to confirm purity and identity
• Delivered as lyophilized powder and packaged under dry argon gas to minimize oxidation
Bio-Synthesis offers a complete range of premium quality peptide products ranging from bulk API polypeptides to high throughput library peptides and peptide array preparation since 1984. We also provide a large number of peptide modifications as well as peptide synthesis for diagnostic and therapeutic applications. Bio-Synthesis specializes in both, liquid phase and solid phase fmoc peptide synthesis chemistry. We have a long standing record in preparing biologically active polypeptides including long, complex and hydrophobic peptides synthesized to your specifications. It is basically the experience in peptide synthesis that Bio Synthesis enjoys the trust of its clients.
For quality satisfaction the sequences are analyzed for hydrophobicity at pH 2 and pH 6.8, aggregation potential, and other known chemistry issues that may arise due to the peptide's amino acid composition. The customer is notified of any potential issues ahead of time so that sequence modifications can be made prior to synthesis when possible. Our peptide design tool provides analysis output for peptide sequences. If specifications of the order are not achieved, the customer is notified immediately and given advice for redesigning the sequence or exploring alternative chemistries.
By using liquid phase and solid phase fmoc peptide chemistries, we have streamlined production with fully automated instrumentation and a 24 hour support group located in Texas. We provide comprehensive oversight to ensure the highest standards of peptide quality.
Solid phase synthesis is performed using optimized Fmoc, Boc methodologies in a state-of-the-art platform for the rapid synthesis of peptide in large and high throughput quantity. Cleavage of peptides is performed using trifluoroacetic acid (TFA), hydrogen fluoride (HF), or other appropriate methods. A good number of the peptides are purified by HPLC using reverse phase C4 and C18 columns. Alternative purification methods (e.g., ion exchange and gel filtration chromatography) are used when needed. After satisfactory QC, the peptides are purified by preparative reverse phase HPLC, freeze dried, packaged and dispatched.
[This message has been edited by catalogpeptide01 (edited 04-05-2015).]
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