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  AnaSpec Now Offers 5-Hydroxymethyl Cytosine Monoclonal Antibody (Clone 4D9)

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Author Topic:   AnaSpec Now Offers 5-Hydroxymethyl Cytosine Monoclonal Antibody (Clone 4D9)
anaspec
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posted 02-19-2014 08:39 PM     Click Here to See the Profile for anaspec   Click Here to Email anaspec     Edit/Delete Message Reply w/Quote
AnaSpec is pleased to announce the availability of a mouse monoclonal antibody specifically recognizing 5-hydroxymethyl Cytosine (5-hmC). This monoclonal antibody (Clone 4D9) is available in a 100 g size. Alternatively, a starter kit containing 50 g each of this antibody and the popular 5-mC (Clone 33D3) monoclonal antibody is also available. Together, these two monoclonal antibodies provide a fully qualified and guaranteed antibody pair for analyzing cytosine methylation pattern in Epigenetics research.

Methylation of cytosine to 5-methylcytosine (5-mC) is a major epigenetic event which interferes with the binding of proteins to DNA resulting in the exquisite control of gene expression and cell differentiation.

5-mC can be further modified to 5-hydroxymethyl Cytosine (5-hmC) by the TET family of methyl-cytosine dioxygenases. 5-hmC is an oxidative product of 5-mC that appears to participate in several active DNA demethylation pathways. 5-hmC is a key marker related to pluripotency in embryonic stem cells and in cancer cells. Hence, this event may be important for normal processes, as well as during cancer cell development and progression.

For more information, please visit https://www.anaspec.com/products/promotions.asp?id=118&col=2&row=3


AnaSpec, EGT Group
AnaSpec, EGT Group is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, amino acids, oligonucleotides, and qPCR MasterMixes. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development, fluorescent dyes, and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.

For more information visit www.anaspec.com

IP: 12.169.96.11

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