home genetic news bioinformatics biotechnology literature journals ethics positions events sitemap


UBBFriend: Email This Page to Someone!
  HUM-MOLGEN
  Biotechnical requests and sources
  AnaSpec Offers PTM Peptide Synthesis

Post New Topic  Post A Reply
profile | register | preferences | faq | search

next newest topic | next oldest topic
Author Topic:   AnaSpec Offers PTM Peptide Synthesis
anaspec
Member
posted 06-25-2012 07:43 PM     Click Here to See the Profile for anaspec   Click Here to Email anaspec     Edit/Delete Message Reply w/Quote
Proteins undergo post-translational modifications (PTM) as a mechanism to expand the coding capacity of genes.1 PTMs found in histone “tails” (amino termini) such as acetylation, methylation and phosphorylation affect chromatin structure and exquisitely regulate gene expression.2-7
The use of synthetic histone peptides containing PTMs has helped unraveled some of the mysteries of PTMs and their interaction with downstream effectors. For example, the use of 15-20 amino acid long histone peptides containing biotin either on the N or C-terminus used in pull-down assays has advanced the understanding of these epigenetic relationships.8-9
At AnaSpec, EGT Group, we are pleased to be a source of premium quality amino acids, whether Fmoc or Boc protected, for PTM peptide synthesis. In addition to PTM lysines and arginines, Fmoc protected phosphorylated D and L-serines and threonines are also available.
Reference:
1. Walsh, CT. et al. Angew. Chem. Int. Ed. 44, 7342 (2005).
2. Grunstein, M. et al. J. Cell Sci. Suppl. 19, 29 (1995).
3. Strahl, BR and CD Allis, Nature 403, 41 (2000).
4. Strahl, BD. et al. Proc. Natl. Acad. Sci. 96, 14967 (1999).
5. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
6. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
7. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
8. Protocol Online http://www.protocol-online.org/cgi-bin/prot/view_cache.cgi?ID=4089.
9. Wysocka, J. Methods 40, 339 (2006).
For more information, please visit http://www.anaspec.com/products/promotions.asp?id=100&col=2&row=3

IP: 12.169.96.11

All times are ET (US)

next newest topic | next oldest topic

Administrative Options: Close Topic | Archive/Move | Delete Topic
Post New Topic  Post A Reply
Hop to:

Contact Us | HUM-MOLGEN

Copyright by HUM-MOLGEN 1995-2017

Powered by: Ultimate Bulletin Board, Version 5.44a
© Infopop Corporation (formerly Madrona Park, Inc.), 1998 - 2000.