posted 12-20-2010 09:19 PM            

Hepatitis C Virus (HCV) belongs to the Flaviviridae family of positive, single stranded RNA. Approximately 170 million people worldwide are infected with this virus and infection results in liver diseases such as chronic hepatitis, cirrhosis and hepatocellular carcinoma.1 Seven major HCV genotypes have been identified which differ in >30 nucleotide sites.2 Genotypes 1, 2 and 3 are found predominantly in the US, Europe, Australia, Japan, Taiwan, Thailand and China; Genotype 4 in the Middle East, Egypt and Central Africa; Genotype 5 in South Africa and Genotype 6 in Southeast Asia.2

AnaSpec, Eurogentec Group also provides HCV NS3/4A mutant proteases. These mutants provide researchers with additional tools to assess the implications and explore a response to the emergence of protease inhibitor resistant NS3 proteases.

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Reference
1. Seeff, LB and JH. Hoofnagle, Hepatology 36, S1 (2002).
2. Imhof, I. and P. Simmonds, J. Virol. 84, 4597 (2010).
3. Sali, DL. et al., Biochem. 37, 3392 (1998).
4. Steinkuhler, C. et al., Biochem. 37, 8899 (1998).
5. Gallinari, P. et al., J. Virol. 72, 6758 (1998).
6. Hardy, RW. et al. J. Virol. 77, 2029 (2003).
7. Hamill, P. and F. Jean, Biochem. 44, 6586 (2005).

About AnaSpec, Eurogentec Group

Since 1993, AnaSpec, Inc is a leading provider of integrated proteomics and genomics solutionsTM for worldwide life science research. As a subsidiary of Eurogentec, AnaSpec offers expertise in peptides, detection reagents, antibodies, assay kits, oligonucleotides, and qPCRs. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. AnaSpec also provides premier custom services including peptide synthesis, antibody production, assay development and oligonucleotide synthesis. AnaSpec is certified to ISO 9001:2008.

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