home genetic news bioinformatics biotechnology literature journals ethics positions events sitemap


UBBFriend: Email This Page to Someone!
  HUM-MOLGEN
  Biotechnical requests and sources
  AnaSpec Introduces New SensoLyte® LSD1 Assay Kit

Post New Topic  Post A Reply
profile | register | preferences | faq | search

next newest topic | next oldest topic
Author Topic:   AnaSpec Introduces New SensoLyte® LSD1 Assay Kit
anaspec
Member
posted 06-23-2009 06:16 PM     Click Here to See the Profile for anaspec   Click Here to Email anaspec     Edit/Delete Message Reply w/Quote
San Jose, CA – June 23, 2009

AnaSpec has announced the release of a new long wavelength assay for Lysine-Specific Demethylase –1 (LSD1), the SensoLyte® LSD1 Assay Kit, Ex/Em=530/590 nm.

LSD1 is a histone-modifying enzyme catalyzing lysine demethylation of histone H3. It plays an important role in regulation of gene expression, acting either as a transcription co-repressor or co-activator.1 The enzyme is implicated in cellular differentiation and has been considered as a potential target for drug discovery.2

The SensoLyteŇ LSD1 assay kit provides a convenient assay for screening of LSD1 inhibitors and for detection of LSD1 activity. This assay consists of two steps. In the first step, LSD1 enzyme is incubated with a methylated peptide substrate and hydrogen peroxide (H2O2) is generated. In the second step, in the presence of peroxidase, H2O2 reacts with fluorogenic substrate to produce fluorescence signal, which is monitored at Ex/Em=530/590 nm.

References
1. Culhane, J. C. et al. Curr Opin Chem Biol. 11, 561 (2007).
2. Shi, Y. Nat. Rev. Genet. 8, 829 (2007).

About AnaSpec

AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

For more information visit www.anaspec.com

###

IP: 12.236.16.122

All times are ET (US)

next newest topic | next oldest topic

Administrative Options: Close Topic | Archive/Move | Delete Topic
Post New Topic  Post A Reply
Hop to:

Contact Us | HUM-MOLGEN

Copyright by HUM-MOLGEN 1995-2017

Powered by: Ultimate Bulletin Board, Version 5.44a
© Infopop Corporation (formerly Madrona Park, Inc.), 1998 - 2000.