posted 08-28-2008 06:23 PM            

AnaSpec has announced the release of two antibodies for growth secretagogue receptor (GHSR). One antibody targets the N-terminus and the other an internal sequence.
GHSR is a G protein-coupled receptor with seven transmembrane domains and is primarily expressed in hypothalamus and pituitary glands (1-4).

GHSR gene is located on chromosome 3q26.31 and results in two products: functional 366 amino acids long GSHR1a and 289 amino acids long GSHR1b protein with yet unknown function1,2. GHSR1a is activated by 28 amino acid peptide ghrelin that is esterified with octanoic acid on Ser3 and must be acylated to induce GHSR response2,3. Activated GHSR modulates phospholipase C signaling route that leads to increase of intracellular calcium ions that stimulate brain cells to release growth hormone and increase appetite 1-4. Recent studies in transgenic mice indicate that GHSR may be responsible for obesity and short normal stature1.

Company Info

AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (including dyes, assay kits, and antibodies) and combinatorial chemistry.

Visit www.anaspec.com for more information.