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  AnaSpec Offers Custom Peptide-Aminoluciferin Synthesis

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Author Topic:   AnaSpec Offers Custom Peptide-Aminoluciferin Synthesis
anaspec
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posted 07-22-2008 01:28 AM     Click Here to See the Profile for anaspec   Click Here to Email anaspec     Edit/Delete Message Reply w/Quote
San Jose, CA July 21, 2008
Aminoluciferin (aLuc) is luciferin with its 6-position hydroxyl group substituted with an amino group. This modification allows aLuc to form peptide (amide) bonds with a peptide, while at the same time retaining the transport and bioluminescent properties of luciferin, resulting in a molecule called peptide-aminoluciferin.1
Many peptides-aminoluciferin are good substrates for luciferase-based (bioluminescence) assays. These substrates generally offer significant advantages, such as increased sensitivity, ease of use, and high throughput screening capacity. Luciferase-based assays are typically 10- to 100-fold more sensitive than comparable fluorescent assays (rhodamine 110, AMC and AFC).
AnaSpec now offers custom synthesis service of peptide-aminoluciferin substrates.
Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry.
For more information, visit www.anaspec.com

Reference:
1. Wilson, B. et al. (Ed.) Advances in Biophotonics. IOS Press, 2005.

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