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 AnaSpec Introduces New Series of PAR Peptides
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| Author | Topic: AnaSpec Introduces New Series of PAR Peptides |
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anaspec Member |
posted 07-07-2008 11:17 PM
   
San Jose, CA – July 7, 2008 AnaSpec, one of the world’s largest providers of catalog peptides, has introduced its latest series of PAR peptides. Protease or Proteinase-Activated Receptors, PARs, belong to the seven transmembrane G-protein coupled family of receptors.1 These receptors are activated when the amino terminus of the receptor is cleaved by specific serine proteases - thrombin (PAR-1, 3 and 4) and trypsin (PAR-2). 2 The cleaved amino end can then act as a tethered ligand on the second extracellular loop of the receptor thereby activating the receptor. 1 Short sequences contained in the amino terminus have been found to activate the receptors on their own, without the need for the protease cleavage. PAR Peptide Series: PAR-1 Agonist, STAL – 2, amide Sequence: SFLLRN-NH2 PAR-1 Agonist, Thrombin Receptor Activator for Peptide 6 (TRAP - 6) Sequence: SFLLRN Scrambled PAR-1 Agonist Sequence: FSLLRN-NH2 Thrombin Receptor (42 - 48) Agonist, human Sequence: SFLLRNP Thrombin Receptor Agonist, amide Sequence: SFLLR-NH2 Thrombin Receptor Agonist Sequence: SFLLR Thrombin Receptor Antagonist Sequence: FLLRN SFLLRNPNDKYEPF, TRAP-14, Thrombin Receptor 42 - 55, human Sequence: SFLLRNPNDKYEPF PAR - 1 Agonist Sequence: TFLLRN PAR - 1 Agonist, amide Sequence: TFLLRN-NH2 PAR - 1 Agonist, amide Sequence: TFLLRNPNDK-NH2 Protease - Activated Receptor - 2, PAR - 2 Agonist, amide Sequence: SLIGKV-NH2 PAR - 3 Agonist, amide Sequence: SFNGGP-NH2 PAR - 1 Agonist, amide Sequence: TFLLRNPNDK-NH2 Protease - Activated Receptor - 4, PAR - 4 Agonist, amide, human Sequence: GYPGQV-NH2 Protease - Activated Receptor - 4, PAR - 4 Agonist, amide, murine Sequence: GYPGKF-NH2 N - 10 Region of TRAP Sequence: DEIKYSEEVC Company Info AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry. For more information, visit www.anaspec.com References: IP: 68.120.108.218 |
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