posted 03-25-2008 12:23 AM            

Leveraging its core antibody and dye technologies, AnaSpec has introduced a suite of labeled and unlabeled anti-Actin antibodies. Labeling options include biotin, conventional fluorescent dyes, and AnaSpec’s proprietary line of HiLyte™ dyes.

Actin is a highly conserved protein of approximately 42-kDa, expressed in all eukaryotic cells. Actin filaments are constituents of the cytoskeleton and play essential roles in regulating cell shape, cell division, cell junctions, cell signaling, and movement. Actins are divided into three classes - alpha, beta and gamma. At least six Actin isotypes have been identified in mammalian cells. Alpha Actins are found in muscle (á-skeletal, á-aortic smooth, á-cardiac, and ã2-enteric smooth). Beta and gamma isoforms are prominent in non-muscle cells. Smooth muscle a-Actin is important because its expression is mostly detected in vascular smooth muscle cells. Anti-Actin antibodies stain smooth muscle cells in vessel walls, gut wall, myometrium, myoepithelial cells, and is reactive with tumors arising from smooth muscles and myoepithelial cells.
Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry.

For more information, visit www.anaspec.com