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Author Topic:   AnaSpec Introduces Twenty-Five New Catalog Peptides
posted 01-24-2008 06:39 PM     Click Here to See the Profile for anaspec   Click Here to Email anaspec     Edit/Delete Message Reply w/Quote
January 24, 2008 – San Jose, CA

This week AnaSpec, one of the world’s largest providers of custom and catalog peptides, introduced twenty-five (25) new catalog peptides.

[Ala28]-beta-Amyloid (1-40)- Cat# 61968-05
This is amino acids 1 to 40 fragment of the beta-Amyloid peptide; modified with the Ala28; replacing Lys28 residue.

Cys Containing b-Amyloid (1-40) Binding Peptide- Cat# 62428
This peptide containing flanking cysteines was shown to bind b-Amyloid.(1-40) polimer form; but not monomeric b-Amyloid (1-40). Such peptides are useful as carrier molecules to deliver therapeutic and diagnostic reagents to amyloid plaques.

Melittin; honey bee- Cat# 62366
Melittin; a 26-residue bee venom peptide; is known to induce murine antibodies specific for its hydrophilic C-terminus of residues 20 to 26 and T cell responses specific for its hydrophobic mid-region of residue 11 to 19. This peptide is the anti-inflammatory agent; it inhibits the lyme disease spirochete.

Mycobacterium Tuberculosis Protein Ag85A- Cat# 62425
This is a T-cell immunodominant CD8 peptide of the Ag85A Mycobacterium tuberculosis protein; MHC class I H-2Ld-restricted epitope. Because parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis; intranasal administration of vector expressing AdAg85A represents an effective way to boost immune protection by parenteral BCG vaccination.

BAD BH3 (103-123)- Cat# 62489
This is amino acids 103 to 123 fragment of BAD BH3 protein. BH3 domain of BAD is necessary for its ability to bind Bcl-2 and Bcl-XL and induce apoptosis. Mutations in this domain of the protein inhibit binding of BAD to Bcl-2 and Bcl-XL resulting in the apoptosis arrest; and possible neoplasia.

BAD BH3 (146-159); Paired- Cat# 62483
This is amino acids 146 to 159 fragment of BAD BH3 protein. This peptide belongs to the pro-apoptotic members of the Bcl-2 family. This non-phosphorylated peptide may be used as a control for the BAD BH3 protein phosphorylated at Ser155 . Phosphorylation at Ser155 inhibits the death-promoting activity of BAD.

Bax BH3 (58-71)- Cat# 62486
This is amino acids 58 to 71 fragment of Bax BH3 protein. Bax is a major proapoptotic member of the Bcl2 family which is required for apoptotic cell death.

Bcl-2 BH3 (85-105)- Cat# 62494
This is amino acids 85 to 105 fragment of Bcl-2 BH3 protein. Cleavage of Bcl-2 loop domain by caspase-3 releases BH3 domain; which is a death-promoting region common to all members of Bcl-2 family. Bcl-2 BH3 domain contains a core sequence LRQAGDFS where Leu1 and Asp6 are critical for the homerization.

Bcl-XL BH3 (85-98)- Cat# 62481
This is amino acids 85 to 98 fragment of Bcl-XL BH3 protein. The Bcl-XL is anti-apoptotic protein.

Bid BH3 (85-98)- Cat# 62485
This is amino acids 85 to 98 fragment of Bid BH3 protein. The BH3 domain of Bid is believed to play an essential role in Bax activation

Bik BH3 (56-69)- Cat# 62487
This is amino acids 56 to 69 fragment of Bcl-2-interacting killer (Bik) BH3 domain. Bik BH3 peptides bind to Bcl-XL and can restore Bax/Bid-induced permeabilization in the presence of Bcl-XL. The BH3 domain of Bid is believed to play an essential role in Bax activation

Ghrelin (1-18)- Cat# 62358
This peptide is amino acids 1 to 18 fragment of ghrelin. Ghrelin is a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a). The entire sequence of ghrelin is not necessary for its activity. The segment Gly-Ser-Ser(n-octanoyl)-Phe appears to constitute the 'active core' required for agonist potency at hGHSR1a; and the 18 amino acid peptide displays some functions of the full length ghrelin peptide.
Sequence: GS-S(n-octanoyl)-FLSPEHQRVQQRKES

VIR-165; Alpha1-Antitrypsin Modification (353-372)- Cat# 62434
VIR-165 is a modified form of virus inhibitory peptide (VIRIP); which corresponds to residues 353 to 372 of C-proximal region of human alpha1-antitrypsin; the most abundant circulating serine protease inhibitor. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains. This modification enhances the antitrypsin ability to inhibit HIV-1infection.

Adeno-Associated Virus Epitope 2 (AAV2)- Cat# 62522
This peptide is capsid derived immunodominant adeno-associated virus 2 (AAV2); CD8 T cell epitope. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T cells.

Catestatin; Chromogranin A (352-372); human- Cat# 62433
Catestatin is amino acids 352 to 372 fragment of chromogranin A (parathyroid secretory protein 1); neuroendocrine secretory protein. Catestatin is an inhibitor of catecholamine release.

CKK-Insulin Receptor Substrate 1 (IRS-1) (979-989); mouse- Cat# 62544
This peptide is amino acids 979 to 989 fragment of the murine insulin receptor substrate 1 (IRS-1) modified with additional residues Cys76; Lys77; Lys78 at the N-terminus. It contains the phosphorylation site at Tyr983.

Glutamate Receptor Endocytosis Inhibitor; control peptide (GluR23A)- Cat# 62548
This control peptide is used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GST–GluR23Y). It was employed to investigate the effect of postsynaptic application of GST–GluR23Y during whole-cell recordings of CA1 neurons in hippocampal slices. Unlike GST–GluR23Y; GST–GluR23A; is not a tyrosine phosphorylation substrate.

Myelin oligodendrocyte glycoprotein (MOG 8-21)- Cat# 62369
This peptide is amino acids 8 to 21 fragment of the myelin oligodendrocyte glycoprotein (MOG). It induces relapsing experimental autoimmune encephalomyelitis (EAE) in mice associated with broadening of the autoimmune repertoire. Subtle changes in MOG (8-21) dramatically influences disease susceptibility and T cell responses in vitro.

Erythropoietin Receptor Peptide (EpoR); pTyr429; acetylated; amide- Cat# 62346
This is amino acids 423 to 438 fragment of the Erythropoietin Receptor Peptide (EpoR); phosphorylated at Tyr429. It binds to the N-SH2 domain that has a function in regulation of the PTPase domain and thereby signal transduction. It activates SHP-1 (previously called PTP1C; HCP; and SHPTP1); a protein-tyrosine phosphatase with two Src homology 2 (SH2) domains predominantly expressed in hematopoietic cells.

Histone 4 (1-20); PRMT7 Substrate; M1- Cat# 62498
This GRG containing peptide is amino acids 1 to 20 fragment of histone 4. It is a substrate for human protein-arginine methyltransferase 7 (PRMT7); a type II methyltransferase capable of producing symmetrical dimethyl arginine (sDMA) modifications in proteins.

Histone 4-12; p300/CBP Substrate- Cat# 62500
This 12 residues long fragment (amino acids 3 to14) of the histone 4; is also known as H4-12. Histone acetyltransferase (HAT) p300/CBP catalyzes the acetylation of this N-terminal tail of free histone H4 at Lys5; 8; 12. Lys8 is thought to be the preferred acetylation site in H4. Determinants of interaction of p300 with histone 4 appear to be fully present on H4-12; the N-terminal region of the protein. H4-12. is functionally equal to the longer H4-21 peptide; despite the loss of nine amino acids.

Histone 4-21; p300/CBP Substrate- Cat# 62499
This sequence is amino acids 1 to 21 fragment of the histone 4. Histone acetyltransferase (HAT) p300/CBP catalyses the acetylation of this N-terminal tail of free histone H4 at Lys5; 8; 12; 16. Lys8 is thought to be the preferred acetylation site in H4. Determinants of interaction of p300 with histone 4 appear to be fully present on H4-21; the N-terminal region of the protein.

NR-Box 2 Peptide- Cat# 62534
This 13-amino-acid peptide belongs to the nuclear receptor (NR)-box 2 proteins. NRs represent a class of regulatory factors that bind to signals; response elements; protein cofactors; and regulate target gene transcription. This sequence includes the conserved LxxLL motif of NR-boxes.

Bombolitin I- Cat# 62506
Bombolitin I is a small amphiphilic peptide isolated from bumblebee venom. At least 5 bombolitins have been characterized. This peptide elicits histamine release from rat peritoneal mast cells.

Influenza Virus Hemagglutinin (326-340)- Cat# 62423
This peptide is amino acids 326 to 340 fragment of the influenza virus hemagglutinin (HA). This HA326 peptide elicits strong gamma interferon (IFN-?) production in the intracellular cytokine assays.

Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry. Established in 1993, AnaSpec's headquarters and manufacturing facilities are located in San Jose, CA.

For more information visit www.anaspec.com


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