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Author Topic:   LabOnWeb.com
posted 03-27-2000 09:45 AM     Click Here to See the Profile for Administrator     Edit/Delete Message Reply w/Quote
The fresh new site LabOnWeb.com, by Compugen, is now providing a three-tiered report on expressed sequences: Genes are elongated, analyzed for expression patterns, and queried for putative function. This is a very useful service not only for those of us who run experiments and end up having many 'candidates', but also for any molecular biologist evaluating genes - this one-stop analysis gives about everything one can learn from the sequence alone.

First, there is 'I-RACE' - the sequence is elongated based on the LEADS databases that Compugen has been developing since 1998. A combination of public and private domain EST and mRNA data, LEADS now represents over 70,000 unique genes. A query sequence is elongated according to the best available transcript in LEADS.
Next, the expression pattern of the sequence is analyzed using SAGE - the popular method to quantify mRNA presence in libraries, based on the 3' end. Even short ESTs or incomplete sequences may have SAGE tags, and tell you allot about the possible tissues where your candidate is expressed.
Then, the elongated sequence is compared for homology in a very nice and useful page, which includes comparisons all major protein, DNA, and domain databases, all neatly organized into a split-screen format with clear graphic designation of 'significance'.
Last, a summary page is presented - giving you all these results, numbers, and graphs as one clear text summary of your query. Sometimes this is all you may need...
Additional services, such a ORF prediction, primer design, and proprietary SAGE libraries, complete the picture of a useful, highly focused site. Currently every new user can enjoy up to 6 free searches.

For more information, you may see the demo, but it is best - for additional information or in order to submit your own sequence - just to go to www.labonweb.com . To use the site just press "Join" and follow the instructions.


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