news archive genetic news - November 2, 2005

November 2, 2005

your information resource in human molecular genetics

-	How A Genetic Mutation Influences Schizophrenia Two groups shed light on the linkage between a genetic mutation and the cognitive and physiological changes that may be involved in schizophrenia.
-	Taking Away The Energy From T Cell Proliferation A new class of immunosuppressive compounds is shown to block T lymphocyte proliferation by inhibiting lactate transport.
-	Discovery Of A Context-Dependent Oncogene The paradoxical behaviour of Krüppel-like Factor 4 (KLF4) - both a tumour-supressor or oncogenic, depending on the context - is explained.
-	Magnetic Nanoparticles For Imaging Human Cell Transplants Scientists have succeeded in using magnetic resonance imaging (MRI) to visualize therapeutic cells transplanted into patients.
-	Embryonic Stem Cells Turned Into Elusive Endoderm Researchers have turned human embryonic stem (hES) cells into a cell type found in human embryos that ultimately forms the pancreas, liver, lungs, and other organs.
-	Microbicide Gel Protects Monkeys Against Simian HIV A potential approach to preventing HIV infection in women is reported.
-	Antagonizing Gene Expression Study shows that a class of specially engineered compounds called 'antagomirs' can effectively silence the action of miRNAs in regulating gene expression.
-	Mapping The Human Genome For Differences To Find The Genetic Causes For Disease Researchers have mapped the most common genetic differences across the entire genome for 269 different humans in unprecedented detail.
-	Non-Coding DNA Shows Adaptive Evolution Paper provides evidence that the non-coding regions of the genome are actually under strong selection.
-	Largest computational biology simulation mimics life's most essential nanomachine Simulating movement of tRNA into the ribosome during decoding
-	Fused Genes Can Trigger Development Of Prostate Cancer Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
-	Flipped Genetic Sequences Illuminate Human Evolution And Disease Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies
-	Counting cytokinesis proteins globally and locally in fission yeast Yale Researchers Make Cell Biology Quantitative
-	Researchers Discover New Gene Regulation Mechanism Messenger RNA "Cut and Run" scheme provides rapid stress response
-	Expression Project For Oncology (expO) Collects 1,000th Malignant Tumor Specimen Gene expression analysis with clinical information on hundreds of these specimens is now publicly available online
-	Molecular drug pump may help reduce risk of Alzheimer's P-glycoprotein deficiency at the blood-brain barrier increases amyloid-b deposition in an Alzheimer's disease mouse model
-	Hormone Might Cause Dangerous Pregnancy Complication The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation
-	Rett gene regulates alternative splicing Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2
-	Major Sequencing Progress Solexa expects to be the first to deliver whole human genome sequencing at $100,000 per genome.