Earliest Animals Had Human-like Genes Species evolve at very different rates, and the evolutionary line that produced humans seems to be among the slowest.
2005-11-29
Alzheimer's Vaccine Reviewed A controversial vaccine that was the subject of a halted trial to prevent cognitive decline in Alzheimer's patients could have the potential to be reformulated to eliminate its toxicity while retaining the benefits.
A Silent Killer Scientists suggest a mechanism that may selectively silence the electrical activity of dopamine producing neurons.
Remote-Controlled Gene Delivery Synthetic gene-delivery system has great implications for the development of targeted gene therapy based on non-viral systems.
Perfect Fit For Immune Recognition Mice lacking a particular enzyme exhibit abnormal immune responses, resulting from a less than perfect fit of protein bits displayed to immune cells.
Activating Smoothened Scientists report on the protein target of a small molecule known to induce stem cell differentiation.
Polycystic Kidney Disease Unravelled New results unravel how two mutated genes operate in causing abnormal cell proliferation in autosomal dominant polycystic kidney disease (ADPKD).
DISC1, Neuronal Development And Schizophrenia A change in the function of a protein in the cerebral cortex may contribute to the subtle neuronal defects observed in the brains of patients with schizophrenia.
Getting Lymphocytes Going Scientists report that 'microclusters' of molecules are the discrete physical structures required for triggering and, importantly, sustaining immune signals.
Allergy Safety Pins Researchers identify the enzyme Pin1 that increases the stability of mRNAs encoding GM-CSF.
Heart Risk From Inflammmatory Gene Variant A common variant of a gene involved in inflammation is 3.57 times more common in African American individuals who have had a heart attack than in African Americans who have not.
Small-Molecule Suppressor Research paper reports a small molecule that suppresses the phenotype of a zebrafish mutation.
Skeletons In Cancer's Closet Scientists have found the mechanism of action of a natural product known to be toxic to cancer cells.
Agonizing Over CD40 A new approach to targeting cellular receptors in the immune system using small molecules.
A Path To Beating Cancer Two studies report promising developments in promoting more targeted and effective cancer treatment regimes in the future.
The Yin and Yang of Appetite Hormones An analysis of the prohormone from which the appetite stimulant ghrelin is derived has uncovered a new appetite suppressant, dubbed obestatin.
2005-11-14
Cell-Specific Targeting of Nanoparticles Through simple chemical modification of nanoparticles, it is possible to create disease-specific agents for diagnostic and/or therapeutic use.
Biorepository for Prostate Cancer The U.S. National Cancer Institute to enhance the quality and availability of various biospecimens and associated data for the broader scientific community for prostate cancer studies.
2005-11-09
New research points to novel therapy for glaucoma New research points to an active role for a tissue previously thought to be metabolically inert and highlights new targets for therapeutic intervention
2005-11-08
Retinal Neovascularization: More Veg, less VegF Anti-VegF therapies dominate the field of retinal neovascular disease but a growing body of evidence suggest that vegetables are just as efficacious
How A Genetic Mutation Influences Schizophrenia Two groups shed light on the linkage between a genetic mutation and the cognitive and physiological changes that may be involved in schizophrenia.
Discovery Of A Context-Dependent Oncogene The paradoxical behaviour of Krüppel-like Factor 4 (KLF4) - both a tumour-supressor or oncogenic, depending on the context - is explained.
Embryonic Stem Cells Turned Into Elusive Endoderm Researchers have turned human embryonic stem (hES) cells into a cell type found in human embryos that ultimately forms the pancreas, liver, lungs, and other organs.
Antagonizing Gene Expression Study shows that a class of specially engineered compounds called 'antagomirs' can effectively silence the action of miRNAs in regulating gene expression.