news archive August 2004

• Scientists Reinvent DNA As Template To Produce Organic Molecules
  By piggybacking small organic molecules onto short strands of DNA, chemists have developed an innovative new method of using DNA as a blueprint not for proteins but for collections of complex synthetic molecules.
  
• Muscles Are Smarter Than You Think
  Acidity Helps Prevent Muscle Fatigue
  
• Genetically Engineered "Marathon Mouse" Keeps On Running
  By enhancing the function of a single protein, researchers have produced a “marathon mouse” with altered muscle composition and enough physical endurance to run twice as far as normal mice.
  
• Listen Up!
  Mice May Hold Key to Restoring Human Hearing Loss
  
• Scientists Establish Database of Genes Associated With Cancer Drug Resistance
  Scientists identified associations between expression of individual ABC transporters in cancer cells and resistance to specific drugs
  
• 'Almost impossible' to catch cheating athletes
  Dr. Tapio Videman is discouraged by how difficult EPO [erythropoietin] is to identify
  
• Stem cell discovery could aid in diabetes treatments
  Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages.
  
• 'Molecular Portals' in Brain Cells Identified
  Infinitesimal particles of gold have enabled neurobiologists to track down key molecules in the machinery of "entry points" in neurons
  
• Drug-Resistant Bacteria May Find New Foe In Novel Drug Design Approach
  At the national meeting of the American Chemical Society researchers report that they have found a way to produce novel aminocoumarins – antibiotics that can help in the fight against drug-resistant bacteria.
  

• Avigen Cleared by FDA to Begin Gene Therapy Trial for Parkinson’s Disease
  Innovative Therapy Designed to Restore Effectiveness of L-Dopa in Late Stages of Illness
  
• Rare Mutations Can Significantly Increase Risk Factor for Heart Disease
  Multiple rare alleles contribute to low plasma levels of HDL cholesterol
  
• Using statistics to decipher secrets of natural mutation
  New mathematical approach for analyzing the complex, subtle patterns of natural mutation in DNA
  
• 'Smart Gene Therapy' Protects Against Damage From Heart Attack
  Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
  
• Molecular Link Between Inflammation And Cancer
  Inactivation of Pro-Inflammatory Gene Dramatically Reduces Tumor Development
  

• Got the time?
  Development of a molecular timetable by analysis of circadian gene expression
  
• Location of Potential Familial Lung Cancer Gene Discovered
  A major lung cancer susceptibility locus maps to chromosome 6q23-25.
  
• Gene Expression Pattern May Predict Behavior of Leukemia
  Expression pattern of miRNA genes in CLL correlated with a deletion of a chromosomal region and with mutations in the Ig gene
  

• Genome-wide discovery of loci influencing chemotherapy cytotoxicity
  New technique helps scientists reveal interactions between genes and drugs
  
• Malignant cancer cells generate mice through cloning
  Nature can reset the clock in certain types of cancer and reverse many of the elements responsible for causing malignancy
  
• Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal mode
  Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of a mouse -- including heart, diaphragm and all limbs
  
• Researchers Look Into Components Of RNA Silencing Machinery
  DNA methylation is independent of RNA interference in Neurospora
  
• Synthetic Prion Causes Neurological Disease In Mice
  The findings demonstrate that prions can make copies of themselves without the presence of viral DNA or RNA, damage brain tissue, and cause neurological diseases
  
• Research Reveals Reveals Gains Or Losses Of Large Segments Of DNA In Healthy People
  These findings point to possible new explanations for individual uniqueness as well as why disease develops
  
• Researchers Uncover Surprising Degree of Large-Scale Variation in the Human Genome
  Implications Seen for Cancer, Neurological Disorders, and Other Diseases
  

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