news archive February 2005

• Parasite Genome Sequenced
  The genome of Entamoeba histolytica has been sequenced providing new insights into the physiology and evolution of this major human pathogen.
  
• Detecting Drug Cheats
  New chip assay effectively detects prohibited drugs in the urine samples of athletes
  
• Blood Expression Profiles May Help Diagnose Schizophrenia
  Accurate diagnoses of mental illnesses could soon be made by assessing gene expression profiles in blood.
  

• Mothers' Exposure To Air Pollutants Linked To Chromosome Damage In Babies
  A new study of 60 newborns in New York City reveals that exposure of expectant mothers to combustion-related urban air pollution may alter the structure of babies' chromosomes while in the womb.
  
• Genotype Browser
  Whole-genome patterns of common DNA variation in three human populations
  
• Test Could Improve Detection Of Prion Disease In Humans
  A highly sensitive post-mortem test could help scientists more accurately determine if a person died of Creutzfeldt-Jakob disease (CJD).
  
• Advances In Uterine Leiomyoma Research: 2nd NIH International Congress
  This conference will bring together researchers to foster an exchange of scientific information among members of the uterine leiomyoma (fibroids) research and health care communities.
  
• Reducing The Pain Of Stem Cell Therapy
  Paper reports that stem cell transplantation treatment can also worsen a problem suffered by some spinal cord injury patients.
  
• Helping Stem Cells Maintain Their Humanity
  Report of a new technique for human embryonic stem cell (hESC) culture that reduces the use of animal-derived compounds, making them potentially safer and more reliable for biomedical applications.
  
• Uncovering the Details of a Viral Secret Weapon
  Data from the rigorous analysis of a variety of viral genomes may provide important new insights into the mechanisms of viral pathogenesis.
  
• Hair Growth Restores Hearing
  A gene therapy approach to replace lost hair cells in the inner ear can improve hearing in deaf mammals.
  
• New Insights Into Muscle Growth Regulation
  Research identifies a way to regulate muscle growth in a way that should minimise the chance of unwelcome side effects, unlike current therapies.
  
• Leptin Regulates Bone Remodelling
  New research into bone structure and function shows how the hormone leptin plays a vital role in these processes, and could help our understanding of osteoporosis
  
• Researcher links schizophrenia, gene mutations
  Altered genes cause receptors to become highly sensitive to their own dopamine, leading to psychosis
  
• Separating Chromosomes Improves Genetic Test Results
  Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer
  
• Researchers Identify Enzyme That Activates Cancer Cell Growth And Invasion
  PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells
  
• The Very Unexpected Life And Death Of A Leukemic Cell
  In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
  
• Gene therapy for Parkinson's disease moves forward in animals
  Continuous low-level glial cell line-derived neurotrophic factor delivery provides neuroprotection and induces behavioral recovery in a primate model
  
• Research Identifies Proteins Crucial To Construction Of Brain's Information Superhighway
  Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis
  
• Asthma Gene Clusters Identified
  Findings Could Lead To New Treatment Based On Individual Genetic Profiles
  

• International Coalition to Fund Autism Genetics Research
  An international public/private partnership of government health agencies and private advocacy organizations has committed more than $21 million for research to identify the genes associated with autism spectrum disorders.
  
• New Neurons Born In Adult Rat Cortex
  NIMH scientists have found newly born neurons that communicate via the chemical messenger GABA (gamma-aminobutyric acid) in adult rat cortex, and striatum.
  
• Bone Density Appears To Recover After Adolescents Discontinue Injected Contraceptive
  Lower bone density appears to recover in adolescent females once they stop using the injected contraceptive depot medroxyprogesterone acetate (DMPA).
  
• DNA Vaccine Banishes TB
  A new gene therapy approach could help completely eliminate the infection that causes one of the world's biggest killers – tuberculosis (TB).
  
• No Longer Bird Brains
  Researchers compared parts of birds' brains with the brains of other animals, including mammals, and concluded that much of a bird's brain are responsible for carrying out advanced functions like those in mammals.
  
• The Truth About Antidepressants And Suicide
  The current controversy over the link between antidepressants and suicidal behaviour in children shouldn't ignore the risks of not treating the disease.
  
• Seeing The Forest Or The Trees
  Left- and right-handers also use different parts of the brain to focus on the whole versus the parts of a visual stimulus
  
• New Function For Pacemaker Neurons
  Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response
  
• Researchers Find New Genes Necessary To Make Embryo
  New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
  
• Discovery Promises Simpler Therapy For Sickle Cell Disease
  Impaired vasodilation by red blood cells in sickle cell disease
  
• Viral DNA Sequence A Possible Trigger For Breast Cancer
  MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells
  
• Search and Destroy: A New Mechanism Of Regulating RNA Degradation
  Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3'UTRs so as to Elicit mRNA Decay
  
• Protein Stops Growth Of Brain Tumor, OHSU Study Shows
  Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma
  
• Blood Test Shows Promise As Monitor For Antiangiogenic Cancer Therapy
  Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis
  
• First U.S. Kidney Cancer Vaccine Trial Underway
  In the study, patients with stage IV renal cell carcinoma are given regular doses of an investigational kidney cancer vaccine, called Trovax, in conjunction with Interleukin-2 (IL-2).
  
• New Inherited Disease Can Cause Early Aortic Rupture
  A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.
  
• How Many Comparative Genomes Are Enough?
  A model of the statistical power of comparative genome sequence analysis.
  
• Scientists Find Genome Structure Responsible for Gene Activation
  Genomic maps and comparative analysis of histone modifications in human and mouse
  

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