home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Serotonin Transporter Gene Associated With Alcohol Consumption In Social Drinkers

 
  March, 9 2005 21:07
your information resource in human molecular genetics
 
     
As alcohol consumption is linked to a growing list of negative health outcomes, our drinking habits are coming under increasing scrutiny. Research has highlighted considerable variation in alcohol intake between individuals, and mounting evidence suggests that these differences are a result of genetic factors. A study in 2004 by John Whitfield and colleagues at the Queensland Institute of Medical Research demonstrated that variation in long-term average alcohol intake is almost entirely due to genetic differences. This finding has prompted molecular genetic research to focus on identifying the precise genes that are important in mediating alcohol consumption.

Alcohol is known to interact directly with several neurotransmitter systems in the brain. The serotonin system, for example, has been linked to several aspects of alcohol abuse, and is also implicated in common comorbid conditions such as depression and anxiety. The serotonin transporter gene (5HTT), which controls the reuptake of serotonin at synapses in the brain, is one gene that has received considerable attention. It contains a functional polymorphism in its promoter region that is known to be associated with altered serotonin activity, with the so-called 'short' form acting to decrease serotonin transporter expression and serotonin reuptake.

In a forthcoming article in the American Journal of Medical Genetics B, Marcus Munafň and colleagues at the University of Oxford examine the relationship between 5HTT genotype and alcohol consumption in a non-alcohol dependent sample of social drinkers in the United Kingdom. They find that the short allele of the 5HTT gene is significantly correlated with increased alcohol consumption. Furthermore, the effect appears to be different in males and females – their results indicate higher alcohol consumption in men with one or more copies of the short allele, while in women consumption was highest among heterozygotes.

Link to article


Message posted by: Jonathan Mill

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2014 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.