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The GenEpi Toolbox: a guide of computational resources for genetic epidemiology
An in press paper describes the GenEpi Toolbox, a guide of computational resources for genetic epidemiology
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PrimerBank: a centralized database of primers for QPCR
A recent paper describes the current state of the PrimerBank database, a centralized resource of primers for QPCR
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The NCBI BioSystems database: a centralized resource for biomolecular systems
A recent paper describes the NCBI BioSystems database, a centralized resource for biomolecular systems
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Phenomizer: a freely available tool for clinical genetics
A recent paper describes Phenomizer, a freely available resource for helping diagnoses in clinical genetics.
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BioGPS: a centralized online resource for gene annotation
A recent paper describes BioGPS, a centralized online resource for gene annotation
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| human genetics and molecular biology news flash
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| 2010-03-12 |
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The GenEpi Toolbox: a guide of computational resources for genetic epidemiology
An in press paper describes the GenEpi Toolbox, a guide of computational resources for genetic epidemiology
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| 2010-02-26 |
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PrimerBank: a centralized database of primers for QPCR
A recent paper describes the current state of the PrimerBank database, a centralized resource of primers for QPCR
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| 2010-02-12 |
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The NCBI BioSystems database: a centralized resource for biomolecular systems
A recent paper describes the NCBI BioSystems database, a centralized resource for biomolecular systems
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| 2010-01-29 |
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Phenomizer: a freely available tool for clinical genetics
A recent paper describes Phenomizer, a freely available resource for helping diagnoses in clinical genetics.
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| 2010-01-15 |
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BioGPS: a centralized online resource for gene annotation
A recent paper describes BioGPS, a centralized online resource for gene annotation
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| 2009-12-11 |
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Brain Adaptations to Sensory Loss
Rehabilitation strategies of blind and deaf individuals should take into consideration the changes in structure and function in the brain following sensory loss.
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Sequencing Small Chips
A technique to sequence small quantities of DNA is published online.
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A Stroke Against Stroke
A new cellular mechanism linked to neuronal damage during stroke is reported.
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Inhibition Present in Absences
An unexpected role of inhibitory activity in promoting epilepsy is reported.
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Assessing Natural Memory
How immune cells remember a natural pathogen varies depending on the route of infection.
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Variant Associated with Alcoholic Liver Disease
A genetic variant known to be associated with nonalcoholic fatty liver disease is also associated with alcoholic liver disease.
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Parkinson's Gene Mutated in Cancer
PARK2, a gene commonly mutated in early-onset Parkinson's disease, is also mutated in glioblastoma, colon cancer and lung cancer.
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Mismatch Associated with Graft-Versus-Host-Disease
A genetic mismatch involving the gene UGT2B17 is associated with risk of acute graft-versus-host-disease.
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High Levels of HLA-C Associated with Slower HIV/AIDS Progression
High levels of the protein HLA-C -- a crucial part of the immune system -- are associated with slower progression of HIV/AIDS.
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Feeding Back on Tumour Initiation
The protein ZEB1 also influences the tumour initiating capacity of pancreatic and colorectal cancer cells, and could possibly promote cancerous cells proliferation once they have reached a new organ.
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The Fasting Fox Protein
The brain protein Foxa2 has a key role in regulating food intake, a mouse study suggests.
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'Bone' Protein Linked to Fever
A protein pair best known for their role in bone remodelling may have an unexpected role in the brain, helping to control fever and female body temperature.
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Metabolite Levels Go Awry in Brain Tumours
Mutations in an enzyme that result in unusually high brain levels of the metabolite 2-hydroxyglutarate (2HG) may contribute to the formation of certain malignant brain tumours.
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Re-Thinking Obesity
Mutations in specific genes fully explain a small but significant subset of patients with obesity and/or type 2 diabetes while genetic factors play a key role in determining susceptibility to both disorders in the broader population.
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| 2009-11-19 |
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A*STAR of Singapore to Launch an Online Publication Promoting its Research
Macmillan Scientific Communications (MSC) and Singapore's Agency for Science, Technology and Research (A*STAR) launch new open access website, A*STAR Research, to highlight some of the best research published by A*STAR's research institutions.
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Understanding Schizophrenia
Dysfunction of neurotransmitter signalling can cause pathological behaviour similar to that seen in schizophrenia.
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The Long Shadows of Adversity
Severe stress suffered at an early age can cause long-lasting changes to gene expression patterns in the mouse brain.
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Damaging DNA from a Distance
Medically used nanoparticles can damage the DNA of cells without crossing cellular barriers in the body.
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Inducible MicroRNA Sponges for Intact Organisms
A method for the tissue-specific inhibition of microRNAs -- which play a key role in regulating gene expression -- is published online.
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Location, Location, Location
A drug that inhibits excitatory activity in the brain can either improve or worsen the progression of Huntington's disease (HD) depending on where on neurons its targets are located.
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Arthritis is Spreading
A mechanism that accounts for the spreading of arthritis between joints is presented in a study.
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Disrupting Lasting Memory
A new protein holds the key to making long-lasting antibody responses in the body.
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Common Genetic Risk Variants for Parkinson's Disease
Two independent studies report that common variants at five genes are risk factors for sporadic Parkinson's disease.
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Exome Sequencing Identifies Cause of Miller Syndrome
Targeted sequencing of the protein-coding regions of the human genome has been used to identify the cause of a rare genetic disorder.
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Variants Associated with Hearing Loss in Children Receiving Chemotherapy Medication
An association between a chemotherapy-induced hearing loss and specific genetic variants has been identified.
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A Deletion is Associated with Neurodevelopmental Problems
A small deletion at a specific region on chromosome 15 is associated with a range of neurodevelopmental problems, including developmental delays and seizures.
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Smoking and Autoimmunity Affect Rheumatoid Arthritis Susceptibility
New insights into the genetic basis of rheumatoid arthritis are reported in two papers.
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Re-Thinking Obesity
Mutations in specific genes fully explain a small but significant subset of patients with obesity and/or type 2 diabetes while genetic factors play a key role in determining susceptibility to both disorders in the broader population.
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Notch Takes a Knocking
A drug that blocks a protein involved in cancer once thought 'un-blockable' has shown promise in a mouse model of leukaemia.
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Speeding Up 'Ethical Stem-Cell' Production
The process of reprogramming mature cells into a stem-cell-like state can be accelerated.
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| 2009-11-02 |
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SARS Attacking the Ribosome
A double attack by the SARS virus on host cell protein synthesis is shown in a study published online.
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Heartbeat Awareness
The neural pathway by which we feel stimuli originating inside our bodies -- such as our heartbeat -- is illuminated by studying an unusual patient with unique patterns of brain damage.
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A Notch in Lung Arteries
The common signaling molecule Notch has a role in pulmonary arterial hypertension, often caused by insufficient oxygen reaching the lungs, as reported in a study.
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Layered Immunologic Memory
Distinct populations of antibody-producing memory immune cells arise due to vaccination.
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Possible Multiple Sclerosis Biomarker
Small molecules of RNA are positively associated with disease relapses in multiple sclerosis (MS) in patients according to a report published online.
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Age-Related Sperm Mutations Associated with Testicular Tumor
A rare type of benign testicular tumor is associated with genetic mutations arising from paternal age-effect mutations, which are inherited from fathers that are older than the population mean.
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A Genetic Region Implicated in Schizophrenia
Duplications of a given DNA sequence on chromosome 16 are associated with schizophrenia.
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CRLF2 Defects in Down Syndrome-Associated Leukemia
A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS).
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Variants Associated with Systemic Lupus Erythematosus
Twelve new genetic variants are associated with increased risk of systemic lupus erythematosus (SLE), according to 2 independent studies published online.
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Ribosome Reactions
Two studies discuss new fundamental properties of the ribosome as well as new ways to manipulate the ribosomal machinery.
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Intravital Imaging Reveals Regulation of Metastasis
Activation of a specific intracellular signalling cascade determines whether cancer cells spread as single cells or as a collective unit, and whether they invade via the lymph system or blood.
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Stem Cells Help Study of Infertility Genes
Researchers have tracked and isolated germ cells derived from human embryonic stem cells and studied which genes are involved in their formation.
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Synapse, So What?
Study shows that certain neurons can exert their inhibitory effects without using the specialized intercellular junctions.
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Cancer Link to Microenvironment
A key signalling pathway that operates in mammary gland connective tissue cells helps to suppress the development of mammary tumours.
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Signalling Pathway Link to Cancer
The NF-kappaB signalling pathway has a vital role in certain cancers
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