news archive March 2005

• Cat Allergies Be Gone
  Novel Therapy Tested in Mice Could Chase Away Cat Allergies
  

• Avian Flu Vaccine Clinical Trial
  NIAID, part of the NIH, recruits for safety clinical trial of a vaccine against H5N1 avian influenza.
  

• Visualizing Alzheimer Disease In The Living Brain
  Japanese scientists describe a new technique for seeing amyloid plaques in living brains using commonly available brain-scanning technology, an important step toward developing an early diagnostic test for this devastating disease.
  
• RNAi Meets ALS
  Two reports show that RNA interference might have therapeutic effects against amyotrophic lateral sclerosis (ALS).
  
• Predicting Stroke Risk In Sickle Cell Anemia
  Study provides a predictive model that can identify sickle cell anemia (SCA) patients at risk of stroke with greater accuracy and faster than current methods allow, which may be useful as a prognostic test.
  
• Wnt Signals Two Ways To A Healthy Gut
  The same signal that ensures that there are cells available to keep your intestine replenished also controls a cell type that is required to defend against bacterial infection.
  
• Tumour Warning In Blood Explained
  Italian researchers have established a genetic mechanism for the long-sought-after link between cancer and blood clotting disorders.
  
• X Makes Its Mark
  Genetic secrets of one of the most intriguing of human chromosomes: the X chromosome revealed.
  
• Vital Fertilization Factor Found
  Researchers have, for the first time, identified a protein on sperm that is essential for fusion with eggs during fertilization.
  

• Hypermethylation of the RELN Gene May Play a Role in Schizophrenia
  Epigenetic factors may explain the reduced expression of Reelin observed in the brains of schizophrenic patients.
  

• Studies Expand Understanding of X Chromosome
  NIH-Supported Research Sheds New Light on the Role of Sex Chromosomes in Health and Disease
  
• Developments in Lung Cancer Treatment
  Bevacizumab Combined With Chemotherapy Prolongs Survival for Some Patients with Advanced Lung Cancer
  

• Serotonin Transporter Gene Associated With Alcohol Consumption In Social Drinkers
  Short allele of the 5HTT gene is correlated with increased alcohol intake
  

• Controlling Breast Cancer
  Scientists have determined the shape of a receptor that is centrally involved in the development of hormone-sensitive breast cancers.
  
• Anti-Wrinkle Treatment
  Report shows that features of premature aging can be reversed in cell culture.
  
• Genetic Factors In Heart Function
  Two studies identify new genetic mutations underlying congenital heart malformations.
  
• New Insights Into Muscle Growth Regulation
  New research has identified a way to regulate muscle growth in a way that should minimise the chance of unwelcome side effects, unlike current therapies.
  
• The Best Muscle Gene Therapy Of All?
  Researchers have identified the optimal means of delivering therapeutic genes to muscle tissues with a single intravenous injection -- an approach that may prove useful for treating heart disease and muscular dystrophies.
  
• DNA Breaks Trigger Degeneration
  Researchers have shown that patients with a neurodegenerative disease known as SCAN1 (spinocerebellar ataxia with axonal neuropathy-1) may have trouble repairing a specific type of defect in their DNA.
  
• Secrets Of HIV Unbound
  Researchers describe the structure of the unbound form of gp120 derived from simian immunodeficiency virus (SIV).
  
• Stem Cell Puzzle Explained
  Study shows how a stem cell can be committed to making a specific type of mature cell, while remaining undifferentiated until it is needed.
  

• Scientists Replicate Hepatitis C Virus in Laboratory
  New In Vitro Model System Will Allow Study of Therapeutics and Virus Life Cycle
  
• Enzyme Shown To Help Protect Genomic Stability
  Findings May Provide Insights into Aging and Cancer
  
• It's Not All Genetic: Common Epigenetic Problem Doubles Cancer Risk In Mice
  Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis
  
• Researchers Find New Technique To Identify Fetal Genetic Material
  Global Gene Expression Analysis of the Living Human Fetus Using Cell-Free Messenger RNA in Amniotic Fluid
  
• Certain Genetic Test Helps Detect Mutations That May Be Missed By Conventional DNA Test
  Researchers have identified a genetic test that when used with DNA testing would detect a higher number of genetic mutations in colorectal cancer patients
  
• Research Advances Quest For HIV-1 Vaccine
  A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective
  
• New Medical Devices Can Cause New Immune Problems
  Research findings could help with design of combination products that are not compromised by adverse host responses
  
• NCI Creates Gene Expression Database Of Normal Human Organ Tissue
  Largest open-source database for normal tissue from human organs
  
• NHGRI Targets 12 More Organisms for Genome Sequencing
  Strategic Mix Includes Marmoset, Skate and the vector of Chagas' disease
  

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