home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Variant Associated with Alcoholic Liver Disease

 
  December, 11 2009 9:35
your information resource in human molecular genetics
 
     

A genetic variant known to be associated with nonalcoholic fatty liver disease is also associated with alcoholic liver disease, according to a study published online in Nature Genetics.

Liver cirrhosis -- scarring of liver -- causes approximately 27,000 deaths each year in the United States. Approximately half of these deaths are alcohol related, although only 10-15% of alcoholics develop cirrhosis. Previously, a genetic variant in the gene PNPLA3 was shown to be associated with nonalcoholic fatty liver disease, a fatty inflammation of the liver that is not related to alcohol use.

David Hinds and colleagues show that variation in PNPLA3 is also associated with clinically evident liver disease in individuals with mixed European and Native American ancestry from Mexico City that have a history of substantial alcohol abuse. This genetic variant may help identify individuals of a similar genetic background who have an increased risk of liver disease.

Author contact:

David A. Hinds (Perlegen, Mountain View, CA)
E-mail: David_Hinds@perlegen.com

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.