20/Dec/1996 | WWW Home Page | E-mail:
IMMUNOGENETICS IMGT DATABASE
The ImMunoGeneTics database, IMGT, is an integrated specialised database containing
nucleotide sequence information of genes important in the function of the immune system.
It collects and annotates sequences belonging to the immunoglobulin superfamily which are
involved in immune recognition, these are the B cell antigen receptor (Immunoglobulin or
Ig), the T cell antigen receptor (TCR) (LIGM-database) and the class I and class II
molecules of the Human Leucocyte Antigens (HLA) system (HLA-database).
An integrated immumogenetics database (IMGT/LIGM) specialising in Ig and TcR is under
development through collaboration between LIGM, IFG and EMBL oustation EBI. This database
consists of the Ig and TcR sequence entries.
LIGM Montpellier :Marie-Paule Lefranc (coordinator)
Veronique Giudicelli,Denys Chaume
EMBL-EBI :Ansar Malik
IFG :Werner Mueller
SRS server: http://www.ebi/srs/srsc
NOTE: Selecting this option will bring you to the SRS qerry interface page, where you have
to select "search Sequence Libraries"
WWW server: http://www.ebi.ac.uk/imgt/
FTP server: ftp.ebi.ac.uk/pub/databases/imgt
E_MAIL server: email firstname.lastname@example.org -- send "help IMGT" in the mail body.
This database is available on CD-ROM as an acompanying database to the EMBL Nucleotide
Sequence Database at nominal cost.
EBI - European Bioinformatics Institute | URL: http://www.ebi.ac.uk
| Tel: +44 (1223) 494417
Cambridge CB10 1RQ,
| Fax: +44 (1223) 494968
15/Dec/1996 | WWW Home Page | E-mail:
GeneCards: a new database integrating
information about gene functions
This new service presents extracts of the data stored in public databases like
GDB, OMIM and SWISS-PROT with the intention of facilitating a brief overview of the
cellular functions of the products of a gene, the diseases in which
have been found, and much more. For example, see GeneCards for the famous BRCA1 or TP53 genes.
Go directly to GeneCards homepage or
to the GeneCards Search Page
4/Dec/1996 | WWW Home Page | E-mail:
GDB - What's
Release of Mapview 2.0
Mapview 2 is a Java applet that displays multiple maps with common markers indicated by
alignment lines. Whole maps or slices can be displayed. Users will have the options of
viewing maps in either Mapview 1 or 2. For help retrieving a map or maps, see Access Points to GDB.
Universal Coordinate Querying
Another option for searching on the basis of location has been added to the query forms. All
Localizations, immediately following Cytogenetic Localization on the query forms, will
use a specified location to search for Genomic Segments (and its subclasses, amplimers,
genes, clones) across all maps in GDB simultaneously based on a common coodinate system.
Other New Features
- The Order attribute of GenomicSegment and its subclasses hasbeen renamed to Related
Segments. The Order class has been renamed to Relationships between Genomic
- The menus that border the top of the details forms have been reorganized.
- When retrieving sequence information from a detail form (Nucleic Acid Sequences),
you will be asked to choose a sequence database, either GSDB (Genome Sequence Database) or
GenBank (at NCBI). This selection will become your default database for future sequence
retrievals, but you can change your preference
at any time.
Large Data Sets in GDB (1-Dec-96)
4/Nov/1996 | WWW Home Page
The Max-Planck-Institute for Molecular Genetics in Berlin, Germany, would like to
announce the availability of IXDB via the WWW.
IXDB is a new database which stores information related to the physical mapping of the
human X chromosome. It also stores data about genes, maps, contigs and several clone
libraries. A graphical map display will be released soon. Objects are provided with links
to other WWW-databases whereever possible.
Comments and corrections are always welcome.
The Child Health Research Project Announces its new Home Page: http://www.ih.jhu.edu/ihhtml/chr.htm
Human Transcript Map
is available at the World Wide Web site: http://www.ncbi.nlm.nih.gov/SCIENCE96/.
The map is discussed in this week's Genome issue of the journal Science (A Gene Map
of the Human Genome).
25/Oct/1996 | WWW
Home Page | E-mail:
Rare Genetic Diseases In Children
"Rare Genetic Diseases In Children: An Internet Resource
Gateway" is a comprehensive directory of resources and Message Board system for
families. Hosted by NYU Medical Center, the Resource Directory links to web sites with
information on disabilities, financial matters, education, specific disease Home Pages,
medical concerns, reference information and support. A Message Board, the "Gateway
Kiosk" has five Topic Boards, including "Life-Link Search" enabling parents
to locate others with similar experiences. Professionals, too, are encouraged to visit the
Kiosk Board and respond to the many inquiries on various diseases now posted.
Home Page: http://mcrcr4.med.nyu.edu/~murphp01/homenew.htm
Resource Directory: http://mcrcr4.med.nyu.edu/~murphp01/frame.htm
Gateway Kiosk: http://mcrcr4.med.nyu.edu/~murphp01/brdmenu3.htm
21/Oct/1996 | WWW Home Page | E-mail:
APOPTOSIS Online: The Apoptosis Information & Communication
APOPTOSIS Online is a free information and communication service provided by ApopNet
for all members of the life science community. The web site features an online discussion
forum, a resume/position depository, and a content-based reference library devoted to
apoptosis-related information. You can communicate with other users, post desired or
available positions, and find information about books, journals, grants, meetings, web
sites, methods, vendors, and review articles related to apoptosis research. Access to
APOPTOSIS Online is entirely free, but a one-time member registration is required.
15/Oct/1996| WWW Home Page
C l i n i c a l
e s e a r c h
This section contains requests from researchers or patients regarding:
collaborative studies, shipment of samples, list of laboratories performing certain
molecular tests, general information on diseases / treatments.
12/Oct/1996 | WWW Home Page | E-mail:
There is a new web resource which tracks updates to 18 medical journals on the web and
builds topical views from the combined tables of contents. Topical views also feature
links to related news stories from PR Newswire.
o Abstracts are searchable.
o All links point back to the original articles or abstracts at the publishers' web sites.
10/Oct/1996 | WWW
Home Page | E-mail:
Call for Editors
At present HUM-MOLGEN serves world-wide approximately 4000 molecular
geneticists and clinicians directly on-line as well as more than 40.000 WWW users from
various disciplines. Being a non-profit organisation, HUM-MOLGENs services to the genetics
community are mainfold.
To maintain, extend and improve our service, we need your support!
Nobel Assembly at the Karolinska Institute has today decided to award the Nobel Prize in
Physiology or Medicine for 1996 jointly to Peter C Doherty and Rolf M Zinkernagel
for their discoveries concerning The Specificity of the Cell Mediated Immune Defence
5/Oct/1996 | WWW Home Page | E-mail:
OPPORTUNITIES IN ASIA: EMERGING SCIENCE
AND EMERGING TRENDS
Science's Next Wave, a Web site published by American
Association for the Advancement of Science (AAAS) and Science magazine, will be presenting
a forum on the changing scientific landscape in Asia.
This forum is part of our Going Public series that addresses scientific
trends and issues of general interest to the scientific community. The Asia forum features
six prominent scientists and scientific administrators from Hong Kong, Japan, Singapore,
and China, who will discuss the reform of scientific education, the changing scientific
job market in Asia, stimulating scientific innovation, and cultural barriers to
innovation, among other topics. The forum be accessible starting on Friday, October 4th.
Featured participants in the forum include:
-- Otto C.C. Lin, and C. C. Hang, engineering faculty from the National
University of Singapore
-- Chia-Wei Woo, president of the Hong Kong University of Science and
-- Hiroo Imura, president of Kyoto University
-- Zhangliang Chen, vice president of Beijing University and director of a
national genetic engineering laboratory
-- Chunli Bai, vice president of the Chinese Academy of Sciences and a
scanning tunneling microscopy expert
Related to the forum, we will also be introducing a new group of young
scientists as correspondents for Science's Next Wave, who will discuss their personal
experiences as research scientists in Asia and offer advice for making the most of
research opportunities in Asia.
These scientists-correspondents for Asia include an intern in the MIT
Japan Program, former participants in the NSF Summer Institutes in Korea and Japan, and a
North American scientist currently working for a prominent Japanese pharmaceutical
company. Science's Next Wave will also be providing links to related web sites for
scientists interested in exploring training and funding opportunities in Asia.
We strongly encourage you to tell your peers and colleagues about the
current Asia features on the Next Wave site. Both the Asia forum and the related
correspondent reports from young scientists will be accessible starting on Friday, October
4th. You are encouraged to direct your comments and career questions to the forum
participants and correspondents via the Web site over the next two months.
The URL for the Next Wave homepage is http://sci.aaas.org/nextwave/
Editors of Science's Next Wave
Science's Next Wave
Survey of trinucleotide repeats in
Program: BlastN - Length of the query sequence:
Additional trinucleotide repeats available from The EST Machine
New Science On-Line
Since the end of October the full text of Science research and news
articles is available (free access through 1996). Fore more information please take a look
Online Tools for Scholars by the Editor-In-Chief Floyd E. Bloom and Science Full Text FAQ.
24/Sep/1996 | WWW Home
Page | E-mail:
Cancer Research: A Public Dialog
You are invited to join a discussion about the perception and realities
of Cancer Research.
Cancer touches millions of lives. In spite of the advances in
understanding the disease that have been made, Cancer Research has failed to deliver the
cure. Millions of dollars are spent on Cancer Research annually, in publicly funded
programs, by charitable foundations and in private research institutes.What are your
perceptions of Cancer Research? Do you think it is money well spent? Are we on the right
track? Was your perception altered by Cancer, if you are a survivor or have a loved-one
suffering from it?
22/Sep/1996 | WWW Home Page | E-mail:
Introductory course in linkage analysis
My intoductory course in linkage analysis is now available for browsing
online or downloading at http://www.gene.ucl.ac.uk/~dcurtis/linkex.html It's a set of
exercises taking people through basic use of the LINKAGE
programs and stuff.
20/Sep/1996 | WWW Home Page | E-mail:
Human 2D PAGE Databases for Proteome Analysis.
The following human databases are available: keratinocytes, transitional
cell carcinomas, MRC-5 fibroblats and urine.
You can display protein names and information on specific protein spots by clicking on the
image of the gel representing the 2-D gel map in which you are interested. Also, you can
search by protein name or organelle or cellular component.
Mouse Atlas Project
The UK MRC Human Genetics Unit in
Edinburgh is currently developing a digital atlas of mouse development and database to be
a resource for spatially mapped data such as in situ gene expression and cell lineage. The
project is in collaboration with the Department of
Anatomy, University of Edinburgh, the Jackson Laboratory,
USA and a European Science Foundation
17/Sep/1996 | E-mail:
Hematology Physicians Discussion List (HEM-Dr)
HEM-Dr (Hematology Physicians Discussion List) is a private mailing list
designed mainly for physicians and the discussion of issues in hematology or blood, bone
marrow or lymph gland disorders. Medical doctors, PhDs, and scientists working in the
field of hematology or hematopathology as well as referring physicians are invited to
participate in this discussion list. Patients and their loved ones who are seeking support
group or hematology-related information are referred to either of two separate lists
called HEM-ONC or MPD-NET.
Hematology deals with the study of both benign disorders of the blood, bone marrow and
lymph glands as well as malignant diseases such as leukemias and lymphomas. HEM-Dr allows
a private network of parties involved in hematology to conduct rapid exchange of informal
discussions on various issues to ultimately foster better patient care and outcome.
To join the list or contact the listowners, write to:
Romeo A. Mandanas M.D.
16/Sep/1996 | WWW Home Page
Looking for molecules playing a central role in the pathogenesis of the disease
you are interested in? Or are you searching for useful monoclonal antibodies
directed against a certain antigen; for the cellular function(s), or the
expression pattern of a certain protein? Then HotMolecBase,
the database about medically interesting molecules, may be
an interesting site to visit. To see what it's all about,
have a look into the typical entry,
or try the
engine. If you cannot
find the information you're searching for,
contact the author,
and send him
some words describing your problems,
so that this ever evolving
web service may adjust
to your needs.
Guidance on Human Subjects Issues in Large-Scale DNA Sequencing
The Human Genome Project (HGP) is now entering into large-scale DNA
sequencing. To meet its complete sequencing goal, it will be necessary to recruit
volunteers willing to contribute their DNA for this purpose. The guidance is intended to
address ethical issues that must be considered in designing strategies for recruitment and
protection of DNA donors for large-scale sequencing.
13/Sep/1996 | WWW Home Page |
Announcing Biochemistry Online, an internet based journal
Can be accessed at http://www.arach-net.com/~jlyon/biochem/index.html
The third issue can be viewed at the following site :
Also, calling for papers for publication in the future issues of the journal.
Querries can be addressed to either Justin Lyon at mailto:email@example.com
or to Vineet Gupta at firstname.lastname@example.org
Editor Biochemistry Online
13/Sep/1996 | WWW Home Page
World Wide Web
version of the NIGMS Human Genetic Mutant Cell Repository catalog is now available
The Repository has human cell cultures available in the following categories: inherited
metabolic disorders, biochemically mutant cell cultures with characterized mutations,
well-characterized chromosomally aberrant cell cultures, CEPH Reference Families, a human
diversity collection, and human/rodent somatic cell hybrid mapping panels. Menus are
provided to allow users to search for cell cultures or DNA samples in a variety of ways,
including Repository number, MIM number, disease description, as well as chromosome
abnormality and number. Chromosome ideograms are provided for human/rodent somatic cell
5/Sep/1996 | WWW Home Page | E-mail:
EDDNAL - European Directory of DNA Laboratories
The European Directory of DNA Laboratories currently provides contact
names and addresses for 283 DNA laboratories and details services on 356 genetic diseases.
The directory has been available since July 1996 as an on-line facility updated regularly.
It is expected to promote information exchange between European centres and to improve the
availability of services for rare genetic conditions. The next development will be to make
available the data collected via a questionnaire addressed to all the listed laboratories.
These data provide information about the kind of diagnostic service offered per disease by
each laboratory i.e. methods, techniques, probes, microsatellites, test kits; availability
of direct/indirect diagnosis, of prenatal/presymptomatic diagnosis; target report time,
experience, research interest, general conditions. It is also planned to link EDDNAL and
HELIX (American directory) sites in due course.