| |
|
|
| |
|
|
| |
HUM-MOLGEN
-> Events
-> Courses and Workshops |
|
|
| |
| |
| |
October 16, 2009 |
|
|
| |
|
|
| |
|
|
|
Royal Pharmaceutical Society of Great Britain, Cambridge
Sunday 16 - Thursday 20 May 2010
Sunday 16 May 17.00 Registration 18.30 Welcome drinks reception 19.15 Course dinner Monday 17 May 08:15 Introduction 08:30 Pharmacodynamics (Equilibrium) Review of steady-state models Steady-state models Kinetics of drug action Initial parameter estimates Design issues and case studies 09:45 Coffee/tea 10:00 Pharmacodynamics (Distributional delays) Steady-state models vs. time delay Basic concepts on distributional delays Modelling QT-data with link models Design issues and case studies 10:45 Hands-on session 1 Inst. equil. models, steady-state, log-linear, sigmoidal Incomplete datasets 12:15 Lunch 13:15 – 16:45 Hands-on session 2 Modeling EEG-data with link models Modeling QT- & MAPD data with link models Design issues and case studies 14:45 Coffee/tea 16:45 Numerical grammar 18:15 Course dinner 19:15 Evening exercise on your own PROGRAMME Tuesday 18 May 08:30 Pharmacodynamics (Turnover A) Residual questions from day 1 Turnover concepts I - ‘The gang of four’ Constant and variable baseline Comparing link- and turnover models Initial estimates Design issues and case studies 09:45 Coffee/tea 10:00 Hands-on session 3 Turnover models I-IV Turnover model I of blood clotting data 12:15 Lunch 13:15 Hands-on 3 cont. Collapsing hysteresis loops Design issues and case studies 15:00 Coffee/tea 15:15 Group exercise – FTIM compound selection Compound evaluations Dose prediction, dose nomogram Assessment of safety margin 17:15 Wrap-up & project exercise 18:15 Course dinner 19:15 QTc lecture PROGRAMME Wednesday 19 May 08:30 Pharmacodynamics (Turnover B) Residual questions from Day 2 The thought process Peak shifts Limited production and loss Synergy by means of turnover models Transduction models Irreversible response Initial parameter estimates 09:45 Coffee/tea 10:00 Hands-on session 4 Turnover models I-IV Comparing IRP and Link Design issues and case studies 12:15 Lunch 13:15 Hands-on session 4 cont. Turnover models I-IV cont. Fitting multiple dose PD data 15:15 Coffee/tea 15:30 Introduction and group exercises Group Exercise I Group Exercise II Group Exercise III 17:15 Wrap-up & group exercise 18:45 Course dinner 20.00 Social programme PROGRAMME Thursday 20 May 08:30 Pharmacodynamics (Adaptation) Residual questions from Day 3 Models for adaptation Tolerance and rebound Feed-back systems Oscillating baselines Initial parameter estimates 09:45 – 12.15 Hands-on session 5 Turnover models I-IV continue Synergy Transduction models Irreversible response Design issues and case studies 10:15 Coffee/tea 12:15 Lunch 13:15 Hands-on session 5 cont. Feedback Analyzing pd data from phase i study 14:15 Experimental design Own datasets Synergy 15:15 Summary 15.30 Close of course
|
|
|
|
|
|
|
|
Organized by:
|
|
Royal Pharmaceutical Society of Great Britain |
|
|
Invited Speakers:
|
|
Dr Johan Gabrielsson Dr Daniel Weiner
|
|
|
|
|
|
|
|
Deadline for Abstracts:
|
|
N/a
|
|
|
|
|
|
|
|
Registration:
|
|
MEMBERS OF RPSGB OR SWEDISH ACADEMY £2,345 NON-MEMBER £2,495 MEMBER (NO ACCOMMODATION OR EVENING MEAL) £1,985 NON MEMBER (NO ACCOMMODATION OR EVENING MEAL) £2,135 COMPLIMENTARY TEXTBOOK (BEFORE 12/02/10) Title Forename Surname
|
|
|
E-mail:
|
|
Events@rpsgb.org
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
Generated by meetings and positions 5.0 by Kai Garlipp
WWW: Kai Garlipp,
Frank S.
Zollmann.
7.0 © 1995- HUM-MOLGEN. All rights reserved.
Liability, Copyright and Imprint. |
|