European School of Genetic Medicine, EuroMediterranean University Centre of Ronzano, Bologna (Italy)
18th -22nd April 2009
This course is submitted to European and Italian credits for Continuing Medical Education (CME). Credits will be assigned to physicians, biologists and pediatric nurses.
This Course is funded by Embo. This course will end with a special session dedicated to the late Prof. Attardi, one of the leading scientists in mitochondrial biology. This last session will be held in Padua in collaboration with the Alma Mater of Giuseppe Attardi. Saturday, April 18 Morning Session- Mitochondrial biology - Morning plenary lectures 08.30 P. Bernardi Bioenergetics of OXPHOS, ROS production and mitochondrial apoptosis 9.15 J. A. Enriquez The mitochondrial respiratory chain: structure, function and plasticity 10.30 I. Holt The structure of mtDNA: Gene organization, replication and expression 11.15 L. Scorrano The mitochondrial network: fusion and fission in biogenesis and disease 12.00 S. Calvo Dissecting the mitochondrial proteome in health and disease 12:45 Questions from students on morning lectures Afternoon Session 14:40 Concurrent Workshops 16:30 Concurrent workshops Sunday, April 19 Mitochondrial diseases 1 - Morning plenary lectures 09.00 A. Torroni Genetic variation of mtDNA in human population genetics, health and disease 9:45 J. Montoya mtDNA mutations in mitochondrial disorders 11:00 V. Tiranti Nuclear disease genes in mitochondrial disorders 11:45 A. Rotig Disorders of respiratory chain cofactors 12:35 Questions from students on morning lectures Afternoon Session 14:40 Concurrent workshops 16:30 Concurrent workshops Monday, April 20 Mitochondrial diseases 2- Morning plenary lectures 09.00 A. S. Wartiovaara Disorders of intergenomic communication 9:45 V. Carelli Mitochondrial biogenesis and compensatory strategies in mitochondrial diseases 11:00 A. Munnich Clinical approach to mitochondrial disease: genetic counselling and its social implications 11:45 P. Chinnery Therapy of Mitochondrial Disorders 12:35 Questions from students on morning lectures Afternoon Session 14:40 Concurrent workshops 16:30 Concurrent workshops Tuesday, April 21 Mitochondrial dysfunction in neurodegeneration, ageing and cancer 09.00 A. Trifunovic Mitochondrial Ageing 9:45 G. Romeo Mitochondria and Cancer 11:00 E. Rugarli Mitochondrial Neurodegeneration 11:45 D. C. Wallace The past, present and future of Mitochondrial Medicine 12:35 Questions from students on morning lectures Free Afternoon Thursday, April 22 Attardi's day in Padua. Organizers: M. Zeviani (Milan, Italy), P. Bernardi (Padua, Italy) Chairpersons: A. Chomyn (Pasadena, USA), J. Montoya ( Zaragoza, Spain)
10.15 Welcome and opening ceremony 10.30 A.Chomyn Per aspera ad astra 10.45 J. Walker Key note lecture - Mitochondrial power: energy and structure 11:30 J. Montoya Mitochondrial DNA structure and function: unraveling the magic circle 12.00 P. Cantatore Mitochondrial transcription and its regulation in animal cells 12.30 P. Bernardi mtDNA Diseases and the Permeability Transition Pore: A New Threshold? Afternoon Session- Attardi's lecture Chairpersons: H. T. Jacobs, M. Zeviani
14.00 D.C. Wallace Attardi's Lecture: Why we Still Have a Maternally Inherited Mitochondrial DNA - Insights into Degenerative Diseases, Aging and Cancer 14.45 I. Holt Three revolutions of the magic circle 15.10 A. J. Enriquez ROS signaling and OXPHOS 15.35 G. Villani Control of mitochondrial OXPHOS: not "just" a question of flux Chairpersons: G. Lenaz, P. Bernardi
16.45 A. Martinuzzi cybrids: a workhorse for the dissection of mitochondrial physiopathology 17.10 A. Trifunovic Are mtDNA mutations driving force of aging?" 18:00 G. Schatz Closing lecture: Critical moments in mitochondrial research - and Giuseppe Attardi
18:45 H.T. Jacobs Concluding remarks
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Invited Speakers:
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DIRECTORS: M. Zeviani(Milan, Italy),V. Carelli (Bologna, Italy), A. Munnich (Paris, France) FACULTY: P. Bernardi (Padua, Italy), S. Calvo( Cambridge, USA), P. Cantatore (Bari, Italy), V. Carelli (Bologna, Italy), P. Chinnery (New Castle, UK), A. Chomyn (Pasadena, USA), A.J, Enriquez (Zaragoza, Spain), I. Holt (Cambridge, UK), A. Martinuzzi (Conegliano, Italy), J. Montoya ( Zaragoza, Spain), A. Munnich (Paris, France),G. Romeo (Bologna, Italy), A. Rotig (Paris, France), E. Rugarli (Milan, Italy), G. Schatz (Basel, Switzerland), L. Scorrano(Geneve,Switzerland), V. Tiranti(Milan, Italy), A. Torroni(Pavia, Italy), A. Trifunovic (Stockholm, Sweden), G. Villani(Bari, Italy), M. Zeviani(Milan, Italy) D. Wallace(Irvine, USA), J. Walker (Cambridge, UK), A. Wartiovaara(Helsinki, Finland)
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