|
|
|
A molecule that makes mammals feel full up has been identified, and drugs that target it may help to treat obesity.
Appetite is regulated, at least in part, in a brain region called the hypothalamus. In a paper published online by Nature, Masatomo Mori and colleagues show that a fragment of the secreted protein NUCB2, dubbed nesfatin-1, is expressed in this control centre and induces a feeling of satiety.
When nesfatin-1 is injected into the brain, rats eat less and begin to lose weight. When nesfatin-1 is blocked, animals eat more.
Author contact:Masatomo Mori (Gunma University Graduate School of Medicine, Maebashi, Japan)
E-mail: mmori@med.gunma-u.ac.jp Abstract available online. (C) Nature press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|