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Developmental control of tumor suppressor gene methylation
Methylation at CpG dinucleotides, the best undersood epigenetic mechanism in mammals, allows cells to silence transcription of particular genes in a relatively stable manner. This process seems to be at work during tumorigenesis in the epigenetic silencing of certain growth inhibitory genes. Contact:
John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
Message posted by: Wouter Kalle
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