home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Why The Brain Makes New Nerve Cells

 
  September, 3 2008 7:44
your information resource in human molecular genetics
 
     

The adult brain requires a continuous stream of new neurons for the maintenance of regions controlling smell and spatial navigation, suggests a paper online in Nature Neuroscience.

Until a few years ago, it was thought that the mature brain gradually loses nerve cells but cannot make any new ones. This dogma has since been overthrown, but whether the few newly generated nerve cells play any important roles is not known.

Ryoichiro Kageyama and colleagues tackled this question by genetically modifying mice to synthesize a fluorescent protein in all adult-born nerve cells, and recording the numbers of fluorescent neurons over the course of one year. Over this time, nearly all neurons in a certain layer of the olfactory bulb -- crucial for smelling -- were replaced with new ones. In the hippocampus, which is essential for spatial learning and memory, about 15% new cells were added.

The authors then investigated whether stopping neurogenesis would interfere with the mice's ability to smell or learn. The team made another mouse line, producing a poisonous protein in all adult nerve cell precursors to kill them. With no new neurons available, the mice's olfactory bulbs shrank -- though their sense of smell surprisingly remained intact for at least four months, suggesting a lot of redundancy in the olfactory circuitry. In contrast, the mice's ability to remember how to navigate a particular kind of maze was lost.

Author contact:

Ryoichiro Kageyama (Kyoto University, Japan)
E-mail: rkageyam@virus.kyoto-u.ac.jp

Abstract available online.

(C) Nature Neuroscience press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.