Adenoviral Expression Of XIAP Antisense RNA Induces Apoptosis In Glioma Cells And Suppresses The Growth Of Xenografts In Nude Mice

Authors:
U Naumann, O Bähr, H Wolburg, S Altenberend, W Wick, P Liston, A Ashkenazi and M Weller

Abstract:
The expression of inhibitor of apoptosis (IAP) family members contributes to the resistance of human cancers to apoptosis induced by radiotherapy and chemotherapy. We report that the infection of malignant glioma cells and several other tumor cell lines with adenoviruses encoding antisense RNA to X-linked IAP (XIAP) depletes endogenous XIAP levels and promotes global caspase activation and apoptosis. more….

Correspondence:
Dr U Naumann, Laboratory of Molecular Neuro-Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Str. 27, Tübingen 72076, Germany.
E-mail: ulrike.naumann@uni-tuebingen.de

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