|
|
|
A genetic variant associated with susceptibility to obesity and diabetes has been reported in a study in the August issue of Nature Genetics.
Philippe Froguel and colleagues conducted a large-scale study, including several thousand individuals with childhood or adult obesity and type II diabetes, to examine the genetic factors predisposing to disease. They identified a gene associated with increased risk of obesity and diabetes. The gene, ENPP1, is involved with the cellular response to insulin, and may interfere with normal insulin induced signals. Higher expression of this protein, as was found in this study amongst children with obesity or diabetes, may mimic the effects of insulin resistance in the brain, where insulin causes appetite suppression. The authors suggest that inherited increased expression of this protein may exaggerate insulin resistance and contribute to excessive fat accumulation. Author Contact: Philippe Froguel (Institut Pasteur de Lille, France)
E-mail: philippe.froguel@good.ibl.fr Also published online. (C) Nature Genetics press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|