New Threat Of Antimalarial Resistance

Artemisinins selectively block the activity of a calcium-pumping protein in malaria parasites. Sanjeev Krishna and colleagues show that a single amino acid residue in this protein can determine this selectivity. When this amino acid is mutated to the corresponding residue found in the related human protein, the activity of the mutant malarial calcium pump is no longer blocked by artemisinins.

This observation suggests that artemisinin resistance could readily develop because a single mutation in the calcium pump protein is all it would take to produce drug-resistant parasites, pointing to the urgent need to develop robust treatment against malaria.

Author contact:

Sanjeev Krishna (St. George's Hospital Medical School, London, UK)
Tel: +44 208 725 5836, E-mail: s.krishna@sghms.ac.uk

Also published online.

(C) Nature Structural & Molecular Biology press release.

Message posted by: Trevor M. D'Souza