|
|
|
| home | genetic news | bioinformatics | biotechnology | literature | journals | ethics | positions | events | sitemap |
Easing Inflammation
|
A new type of therapy that targets a key enzyme in a specific type of white blood cell eases inflammation in mice, a Nature paper reveals. It's hoped that the study will aid the development of anti-inflammatory therapeutics for conditions such as rheumatoid arthritis and atherosclerosis. Michael Czech and colleagues designed several small interfering RNAs (siRNAs), all of which silence the expression of an enzyme called mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) in macrophages. In turn, the white blood cells produced fewer inflammatory molecules, easing symptoms and promoting the survival of mice with an experimentally induced form of inflammation. The new method represents an important advance, not least because the siRNA is encapsulated and given orally, but also because its effects are restricted to a target cell type. It is also up to 250 times more potent in vivo than previous reported, systemically delivered siRNAs. CONTACT Michael Czech (University of Massachusetts Medical School, Worcester, MA, USA) (C) Nature press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser. Use the links below to share this article on the social bookmarking site of your choice. Read more about social bookmarking at Wikipedia - Social Bookmarking |
The NCBI BioSystems database: a centralized resource for biomolecular systems Phenomizer: a freely available tool for clinical genetics BioGPS: a centralized online resource for gene annotation Brain Adaptations to Sensory Loss Sequencing Small Chips A Stroke Against Stroke Inhibition Present in Absences Assessing Natural Memory Variant Associated with Alcoholic Liver Disease Parkinson's Gene Mutated in Cancer Mismatch Associated with Graft-Versus-Host-Disease more news ... |
Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp,
Frank S. Zollmann.
7.0 © 1995-2010 HUM-MOLGEN. All rights reserved.
Liability, Copyright and Imprint.