A Rogue Neighbourhood

May, 1 2008 8:55

Gene expression changes in the tissue microenvironment in which a tumour arises can be used to predict outcome in patients with breast cancer, suggests a report online in Nature Medicine.

Analysis of the genes expressed in cancer has provided important information that can help predict the aggressiveness of tumours and their likely response to therapy. Morag Park and colleagues show that the tumour connective tissue or 'stroma' also undergoes changes in gene expression that can help inform disease outcome. By analyzing the tissue surrounding breast tumours, they identify a gene signature that classifies tumours according to clinical outcomes, independent of other prognostic factors.

In addition to providing a new diagnostic tool for breast cancer, these findings highlight the emerging role of tumour stroma in cancer progression.

Author contact:

Morag Park (McGill University, Montreal, Quebec, Canada)
E-mail: morag.park@mcgill.ca

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News

Fighting Glioma-Associated Edema

Strength In Numbers

Generating Human Autoimmune Cells

Genetic Susceptibility To Obesity

Stopping DNA Synthesis Before It Starts

Stem-Cell Regeneration Of The Breast Relies On Adhesion

Targeting Dormant Leukaemia Cells

Insight Into Devastating Pregnancy Condition

Starting Out On The Road To Maleness

Why We Are All Different

New Program For Analysis Of Haplotype Associations

A Rogue Neighbourhood

more news ...