Oxford Global, The Westin Boston Waterfront Hotel 425 Summer Street Boston Massachusetts 02210 United States
3-4 October 2016
The Event In keeping with Oxford Global’s highly successful Genomics and Genetics Research series, an expert panel of 80 speakers will present a full conference programme covering the topics outlined below: Day 1 – Therapeutic Applications of Genome Editing • Cutting edge therapeutic applications of genome editing tools: CRISPR/Cas9, TALEN and ZFN • Therapeutic application case studies: from simple genetic disorders to diseases involving multiple genes • Therapeutic areas will include: o Immunotherapies o Cardiovascular diseases o Genetic disorders o Muscular dystrophy o HIV o Cystic Fibrosis • Genome editing approaches to accelerate drug discovery, target identification, validation and screening
Day 2 – Genome Editing Techniques • Overcoming challenges in CRISPR and other genome editing tools o CRISPR Cas9 system o Zinc-finger nucleases o TALENs o Nucleic acid delivery systems • Achieving editing and control at whole-genome scale • Development of delivery solutions for genome editing • Genome editing towards cell line engineering and disease model development • Design of CRISPR targets using bioinformatics tools • Generation of gene knockouts/ knock-ins • Target validation using the most current gene-editing technologies Co-located 2nd Annual Next Generation Sequencing USA Congress Next Generation Sequencing USA Congress Day 1 Stream 1 – Advances in NGS Platforms and Key Therapeutic Applications • DNA, RNA & proteins sequencing technologies • Effective sample preparation • Assessment of NGS technologies and platforms • Latest innovations: gene editing technologies in NGS • Applications of NGS in medicine and therapeutic case studies o Cancer o Immunotherapy o Biomarkers o Genomic medicine Day 1 Stream 2 – NGS Data Management and Bioinformatics • Developments in NGS analysis techniques and technologies • Comparison in practical use of NGS platforms and software • Integration of ‘omic’ data sets • Genetic and genomic data analysis • Advanced bioinformatics & computational genomic analysis tools • Big data, & cloud computing & data storage strategies in NGS Day 2 Stream 1– NGS Clinical Applications & Diagnostics • NGS in the clinic: case studies including cancer and tumour testing • Using NGS for precision & personalised medicine • Supporting clinical decision-making through genomic sequencing • Novel technology and platforms for NGS data analysis • Integration of technologies and data sets
Co-located 3rd Annual Single Cell Analysis Congress: Single Cell USA Congress Day 1 Stream 3 – Single Cell Analysis and Transcriptomics • Single cell ‘omics case studies and therapeutic applications: o Genomics o Transcriptomics o Proteomics • Understanding clinical & diagnostic importance of single sell analysis • Methods and applications of single cell study for CTCs and rare cell diseases • Single cell genomics for understanding tumour heterogeneity • Single cell RNA sequencing technologies and applications
Day 2 Stream 2 – Single Cell Analysis Technologies • Methods for single cell isolation, capture & purification • Single cell analysis tools including PCR analysis technologies • Clinical applications & future perspectives • High throughput in-situ sequencing approaches • Microfluidics technologies and advances in applications • The potential applications of single cell manipulation
Day 2 Stream 3 – Overcoming Key Single Cell Analysis Challenges • Sample preparation for single cell analysis • Bioinformatics challenges: o Calling copy number variations o Single cell data-handling o Identifying mutated genes in tumor samples o Improving the accuracy of quantitative analysis of transcripts • Data analysis and interpretation hurdles • Strategies and applications for single cell gene expression study
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