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Oxford Global, Novotel London West, London, UK
20th & 21st April 2015
Day 1 Stream 1 – Protein Purification & Downstream Processing - Overcoming purification challenges: membrane proteins, multiprotein complexes, incorrectly folded proteins
- Overcoming purification challenges: membrane proteins, multiprotein complexes, incorrectly folded proteins
- Optimizing protein purification with integrated and continuous processing
- Combined chromatography and ultrafiltration methods
- High-throughput process development & scale-up considerations
Day 1 Stream 2 – Antibody Discovery & Engineering - Novel strategies for antibody engineering: Fc engineering and antibody-drug conjugates
- Antibody library design: achieving flexibility and diversity
- Viral and cellular display platforms: antibody selection & affinity enhancement
- Case studies: amplification methods, in-silico modelling and humanized antibody synthesis
- Chimerisation and screening: analysing antigen binding affinity, specificity and expression
Day 2 Stream 1 – Protein Expression & Characterisation - Evolving methodologies: transient expression, lentiviral expression, co-expression
- Biophysical characterisation: higher order structure and conformation
- Characterisation of antibody drug conjugates and new biotherapeutics
- Novel technologies: glycosylation control, protein labelling, HDX mass spectrometry
- Expression system case studies: bacterial, mammalian, cell-free, algae
- Protein glycosylation: structural characterisation and analysis
- Engineering CHO cells for optimized protein expression
Day 2 Stream 2 – Therapeutic Antibodies & Alternative Scaffolds - Antibodies to target ion channels
- Immuno-oncology: insights into the next wave of antibody therapies
- The implications of microRNAs for cancer therapy
- Emerging armed antibody therapeutics
- Beyond oncology: case studies in neurodegenerative diseases and inflammation
- Novel methods to improve PK/PD and drug delivery
- Alternative scaffolds as emerging therapeutic proteins
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Organized by:
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Oxford Global |
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Invited Speakers:
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Nicolas Fischer Head of Research, NovImmune Stefan Geschwinder Principal Scientist, AstraZeneca Dina Anderson Senior Principal Scientist, Syntaxin Rob Howes Associate Director, HTS, Antibody Discovery and Protein Engineering, MedImmune
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Deadline for Abstracts:
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Please contact Danielle Dalby on d.dalby@oxfordglobal.co.uk or call +44 (0)1865 248455
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Registration:
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For More Information please contact Danielle Dalby D.dalby@oxfordglobal.co.uk 01865 248455
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E-mail:
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d.dalby@oxfordglobal.co.uk
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