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Bioprocess miniaturization: Development and optimisation

 
  June 27, 2013  
     
 
Euroscicon, Cineworld: The O2, Peninsula Square, London, UK
Tuesday, 26 November 2013


9:00 – 9:45        Registration


9:45 – 10:00      Introduction by the Chair:  Professor. Chris Lowe, Department of Chemical Engineering and  Biotechnology, University of Cambridge, UK


10:00 – 10:30    Talk title to be confirmed

                        Dr Martina Micheletti, The Advanced Centre for Biochemical Engineering, University College London, UK 

10:30 – 11:00     Confinement phenomenon based bio-process intensification using monolithic microreactors

                        Professor Galip Akay, School of Chemical Engineering and Advanced Materials, Newcastle University

Bio-Process intensification, B-PI  (by a factor of 5-200 fold compared with batch processing) is achievable using monolithic microreactors with well defined  physical and biochemical structure of pores used as support for bacteria or cells. This enhancement is due to 'confinement phenomenon' in which the behaviour of microorganisms is dependent on their confining environment. Recent examples of B-PI  pioneered at Newcastle University include fermentation, antibiotics and enzyme production as well as tissue engineering and Agri-Process Intensification through bacterial nitrogen fixation by plants. Mechanism of B-PI will be discussed.


11:00 – 11:30     Speakers’ photo then mid-morning break and poster exhibition and trade show


11:30 – 12:00     Lyophilised Biopharmaceticals- Looking at Cake Properties

Dr Daryl R Williams, Director of Development, Discovery Space and Reader in Particle Science,  
Department of Chemical Engineering, Imperial College

An innovative method for the mechanical testing of freeze-dried biopharmaceutical cakes in situ vials has been developed. This simple and quick compression test allows a range of cake mechanical properties to be assessed quantitatively. It can be readily applied to fragile and moisture sensitive freeze-dried cakes within the vials. Freeze dried mannitol, sucrose and trehalose samples all yielded linear compressive elastic behavior for small strains with Young's Moduli of 25, 120 and 170 kPa respectively. This method discriminates readily between the three excipients reported here and can be used to optimise formulation of biopharmaceutical systems.


12:00  – 12:30    Oral Presentations


12:30  – 13:30    Lunch, poster exhibition and trade show

 

13:30 – 15:00     Question and Answer Session


15:00 – 15:30     Afternoon Tea,  last poster session  and trade show

   

15:30 – 16:00    Talk title to be confirmed

                        Speaker to be confirmed
Applikon Biotechnology, UK


16:00 – 16:30    Talk title to be confirmed
Speaker to be confirmed
m2p-labs

16:30 - 17:00     Chairman’s summing up

 
 
Organized by: Euroscicon
Invited Speakers:

Chris Lowe's group's primary research interest is in healthcare biotechnology, particularly where it is applied to the high-value low-volume sectors of biopharmaceuticals, sensors and diagnostics and microbial technology. The work is highly multidisciplinary and not only covers aspects of molecular biology, biochemistry, microbiology, chemistry, physics, electronics and engineering, but also the entire range from fundamental science to strategic and applied science, much of which has significant commercial application.

Galip Akay holds the established chair of Chemical Engineering at Newcastle University. He has a multi-disciplinary education and research background both in academia and industry. He is one of the founders of Process Intensification in chemical technology. More recently, he extended this discipline to biotechnology, tissue engineering and agriculture through the discovery of the 'confinement phenomenon'.  His research in energy and materials science is commercialised by 3 spin-out companies in collaboration with international companies. He has some 250 publications and over 70 patents. He is a founding trustee of  the UK Children's Neurological Research Campaining.

Daryl R. Williams has a B.Sc.(Hons) from University of Melbourne, Australia, a M.Sc. from Lehigh University, USA before completing his Ph.D at Imperial College London where he is the Reader in Particle Science. Daryl has published over 70 journal papers, has 5 patents and is a world leader in advanced instrumental characterisation of solids.  He is the founder of Surface Measurement Systems. He researches the surface/bulk characterisation of organic solids including biopharmaceutics,  as well as their manufacture using spray and freeze drying, crystallisation, freeze drying, milling and granulation.  Sponsors include EPSRC, BBSRC, Pfizer, Astra-Zeneca, P&G, BTL, Avecia and GSK.

Dr Martina Micheletti, The Advanced Centre for Biochemical Engineering, University College London, UK  

Professor. Chris Lowe, Department of Chemical Engineering and Biotechnology, University of Cambridge, UK

 

 
Deadline for Abstracts: July 10th 2013
 
Registration: http://www.regonline.co.uk/Mini2013
E-mail: enquiries@euroscicon.com
 
   
 
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