Colocated with CONCUR 2012, Newcastle upon Tyne
03/09/2012
The goal of systems biology is to provide a system-level understanding of biological
systems by unveiling their structure, dynamics and control methods. The intrinsic
multi-scale nature of these systems, both in space, in organization levels, and in time,
makes extremely difficult to model all of them in a uniform way, e.g. by means of
differential equations or discrete stochastic processes. Furthermore such models are
often not easily amenable to formal analysis and simulation at the organ or even the
cell level is frequently impractical. Indeed, an important open problem is finding
appropriate computational models that scale well for both the simulation and formal
analysis of biological processes. Hybrid modeling techniques, combining discrete and
continuous processes, are gaining more and more attention in systems biology, and
they have been applied to successfully capture the behavior of several biological
complex systems, ranging from genetic networks, biochemical reactions, signaling
pathways and cardiac tissues electrophysiology.
This workshop aims at collecting scientists working in the area of hybrid modeling
applied to systems biology, in order to discuss about current achieved goals, current
challenges and future possible developments.
Topics of interest include, but are not limited to:
* Hybrid models of biological systems (case studies of genetic, cellular networks,
models of tissues, etc.)
* Computational and mathematical analysis techniques for hybrid systems
(i.e. reachability, model checking, abstract interpretation, bifurcation theory
for hybrid dynamical systems, etc.), with applications in Systems Biology.
* Hybrid system identification techniques (learning the model from the experimental
data)
* Efficient simulation techniques for hybrid systems.
* Hybrid modeling languages for biological systems.
* Hybrid systems coping with incomplete and uncertain information.
* Sensitivity analysis for hybrid systems.
* Behaviour-driven parameters identification for hybrid systems.
* Analysis and simulation tools.
We solicit the submission of unpublished results that address on both theoretical and
applied aspects of hybrid modeling techniques in systems biology.
The proceedings will be published in the Electronic Proceedings in Theoretical Computer
Science (EPTCS) series. A special issue in a journal will be considered at the end of the workshop.
Paper submission
Full papers should be no more than 15 pages long, typesetted in the EPTCS-style.
Electronic submissions of abstracts and of full-length papers (in PDF format), can be done through
the online submission system: https://www.easychair.org/conferences/?conf=hsb2012
Important dates
June 15, 2012 - Abstract submission deadline
June 22, 2012 - Full paper submission deadline
July 30, 2012 - Notification of paper acceptance
August 7, 2012 - Camera-ready of accepted papers
Program co-chairs
Ezio Bartocci, University of Stony Brook, USA
Luca Bortolussi, Univerity of Trieste, Italy
Program committee
Marco Antoniotti, University of Milano Bicocca
Gregory Batt, INRIA Paris-Rocquencourt, France
Alberto Casagrande, University of Trieste, Italy
Edmund Clarke, Carnegie Mellon, USA
Thao Dang, VERIMAG Lab, Grenoble, France
Alexandre Donzé, VERIMAG Lab, Grenoble, France
James R. Faeder, University of Pittsburgh, USA
Jasmin Fisher, Microsoft Research, Cambridge, UK
Vashti Galpin, University of Edinburgh, UK
Colas Le Guernic, NYU, USA
Oded Maler, VERIMAG Lab, Grenoble, France
Emanuela Merelli, University of Camerino, Italy
Bud Mishra, NYU, USA
Carla Piazza, University of Udine, Italy
Alberto Policriti, University of Udine, Italy
Scott A. Smolka, University of Stony Brook, USA
Gouhei Tanaka, University of Tokyo, Japan
Verena Wolf, Saarland University, Germany
Paolo Zuliani, Carnegie Mellon, USA
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