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Iowa State University, Ames, Iowa
Sept 18-21, 2008
This symposium is focused around the topical subject of Extracellular and Membrane Proteases in Cell Signaling. The meeting will bring together speakers from the cutting edges of this field, including a range from basic to more applied approaches. It will encourage the presentation of the newest findings, and will aim to promote intensive exchange of information from disparate areas of the field, discussion of mechanisms, and potential collaborations. It will provide the opportunity for students and younger researchers to gain a working knowledge of the current state of the field and the researchers who are expanding it.
Although the roles in signaling pathways of intracellular proteases such as the caspases and ICE are well defined, this is not true for many membrane localized and secreted proteases. Despite this ambiguity, the involvement of secreted proteases in signaling and their importance to normal physiology and many diseases are well-recognized. Because a conference is often a means of pushing the field forward by promoting discussions amongst those who are involved in the research, the less well-defined area of extracellular and membrane proteases in signaling is the focus of this symposium rather than the better defined intracellular protease systems.
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Organized by:
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GFST Symposium |
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Invited Speakers:
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Membrane Proteases and Signaling by the EGF receptor and Notch
Lynn Matrisian: Vanderbilt University, Nashville, Tennessee Matrix Metalloproteinases as mediators of cellular communication Mien-Chie Hung: MD Anderson Cancer Center, Houston, Texas A novel mechanism for nuclear translocation of receptor tyrosine kinases Carl Blobel: Cornell University, New York ADAMs, key molecules in EGF-receptor signaling Conor Lynch: Vanderbilt University, Nashville, Tennessee MMPs: Essential regulators of the vicious cycle of bone metastasis Bin-Bing Zhou: Wyeth Pharmaceutical, Pearl River, New York Targeting ADAM-mediated Signaling for Cancer Drug Discovery Howard Crawford: SUNY Stony Brook, New York Notch Activation by ADAMs and MMPs in Pancreatic Disease Matthew Freeman: MRC Laboratory of Molecular Biology, Cambridge, UK Rhomboids and growth factor signalling
Protease Activated Receptors
JoAnn Trejo: University of North Carolina - Chapel Hill Regulation of Protease-activated Receptor Signaling Wolfram Ruf: The Scripps Research Institute (TSRI), La Jolla, California Regulation of Inflammation by Protease Signaling Heidi Hamm: Vanderbilt University, Nashville, Tennessee Thrombin-mediated G protein signaling pathways Athan Kuliopulos: Tufts - New England Medical Center, Boston, MA Metalloprotease-PAR1 Signaling in Cancer Invasion and Angiogenesis
Cytokine and Chemokine Processing
Chris Overall: University of British Columbia, Vancouver, Canada Signaling Change: New Roles For Proteases Revealed by Degradomics Bill Parks: University of Washington, Seattle, Washington Regulation of Innate Immunity by MMPs Stella Tsirka: University Medical Center at Stony Brook, New York Tissue plasminogen activator and microglia activation in neurodegenerative disease
ECM and Cell Surface
Thomas Bugge: National Institutes of Health, Bethesda, Maryland The intracellular pathway of collagen degradation in tissue development and malignancy Luisa Iruela-Arispe: UCLA, Los Angeles, California Intersection of growth factors and extracellular matrix during vascular morphogenesis Steve Weiss: Life Sciences Institute, Ann Arbor, Michigan MT-MMP-Dependent Remodeling of the Extracellular Matrix Valerie Weaver: University of California - San Francisco, California Influence of extracellular matrix composition and organization during development and tumorigenesis
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Deadline for Abstracts:
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July 18, 2008
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Registration:
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REGISTRATION DEADLINE: August 15, 2008
REGISTRATION COSTS: Registration includes meals (Thursday dinner through Sunday breakfast) and admission to lectures, posters and oral presentations. Advance registration (until August 15): $500 (faculty and staff), $400 (students and postdocs). Registration after August 15: $550 (faculty and staff), $450 (students and postdocs).
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E-mail:
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gfst@iastate.edu
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