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Symposium on Extracellular and Membrane Proteases in Cell Signaling

  March 10, 2008  
Iowa State University, Ames, Iowa
Sept 18-21, 2008

This symposium is focused around the topical subject of Extracellular and Membrane Proteases in Cell Signaling. The meeting will bring together speakers from the cutting edges of this field, including a range from basic to more applied approaches. It will encourage the presentation of the newest findings, and will aim to promote intensive exchange of information from disparate areas of the field, discussion of mechanisms, and potential collaborations. It will provide the opportunity for students and younger researchers to gain a working knowledge of the current state of the field and the researchers who are expanding it.

Although the roles in signaling pathways of intracellular proteases such as the caspases and ICE are well defined, this is not true for many membrane localized and secreted proteases. Despite this ambiguity, the involvement of secreted proteases in signaling and their importance to normal physiology and many diseases are well-recognized. Because a conference is often a means of pushing the field forward by promoting discussions amongst those who are involved in the research, the less well-defined area of extracellular and membrane proteases in signaling is the focus of this symposium rather than the better defined intracellular protease systems.
Organized by: GFST Symposium
Invited Speakers: Membrane Proteases and Signaling by the EGF receptor and Notch

Lynn Matrisian: Vanderbilt University, Nashville, Tennessee
Matrix Metalloproteinases as mediators of cellular communication
Mien-Chie Hung: MD Anderson Cancer Center, Houston, Texas
A novel mechanism for nuclear translocation of receptor tyrosine kinases
Carl Blobel: Cornell University, New York
ADAMs, key molecules in EGF-receptor signaling
Conor Lynch: Vanderbilt University, Nashville, Tennessee
MMPs: Essential regulators of the vicious cycle of bone metastasis
Bin-Bing Zhou: Wyeth Pharmaceutical, Pearl River, New York
Targeting ADAM-mediated Signaling for Cancer Drug Discovery
Howard Crawford:  SUNY Stony Brook, New York
Notch Activation by ADAMs and MMPs in Pancreatic Disease
Matthew Freeman: MRC Laboratory of Molecular Biology, Cambridge, UK
Rhomboids and growth factor signalling

Protease Activated Receptors

JoAnn Trejo: University of North Carolina - Chapel Hill
Regulation of Protease-activated Receptor Signaling
Wolfram Ruf: The Scripps Research Institute (TSRI), La Jolla, California
Regulation of Inflammation by Protease Signaling     
Heidi Hamm: Vanderbilt University, Nashville, Tennessee
Thrombin-mediated G protein signaling pathways
Athan Kuliopulos: Tufts - New England Medical Center, Boston, MA
Metalloprotease-PAR1 Signaling in Cancer Invasion and Angiogenesis

Cytokine and Chemokine Processing

Chris Overall: University of British Columbia, Vancouver, Canada
Signaling Change: New Roles For Proteases Revealed by Degradomics
Bill Parks: University of Washington, Seattle, Washington
Regulation of Innate Immunity by MMPs
Stella Tsirka: University Medical Center at Stony Brook, New York
Tissue plasminogen activator and microglia activation in neurodegenerative disease

ECM and Cell Surface

Thomas Bugge:  National Institutes of Health, Bethesda, Maryland
The intracellular pathway of collagen degradation in tissue development and malignancy
Luisa Iruela-Arispe: UCLA, Los Angeles, California
Intersection of growth factors and extracellular matrix during vascular morphogenesis
Steve Weiss: Life Sciences Institute, Ann Arbor, Michigan
MT-MMP-Dependent Remodeling of the Extracellular Matrix
Valerie Weaver: University of California - San Francisco, California
Influence of extracellular matrix composition and organization during development and tumorigenesis
Deadline for Abstracts: July 18, 2008


REGISTRATION COSTS: Registration includes meals (Thursday dinner through Sunday breakfast) and admission to lectures, posters and oral presentations.  Advance registration (until August 15): $500 (faculty and staff), $400 (students and postdocs).  Registration after August 15: $550 (faculty and staff), $450 (students and postdocs).

E-mail: gfst@iastate.edu
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