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Intracellular and Intercellular Signaling in Dendritic Cell Function

  June 15, 2006  

Keystone Symposia, Keystone, Colorado
February 25 - March 2, 2007

The myriad of cellular interactions that ultimately regulate immune responses are mediated by specific ligand-receptor interactions that, in turn, trigger intracellular signaling pathways. Recent advances in basic cellular and molecular immunology have provided a framework for understanding how the immune response is initiated and regulated, integrating different cell types, molecules and signaling pathways. The Keystone meeting will focus on the immunomodulatory capacity of dendritic cells (DC), a critical cell type in immune regulation. Particular emphasis will be placed on the following. • Receptors that play an important function in pathogen recognition by DC as well as receptors involved in DC processes such as cell adhesion, migration and signaling • The potential role of activating and inhibitory ligands and receptors in modulating DC function • The intracellular signaling triggered by these receptors and the mechanism by which they activate or inhibit immune effector functions and determine cellular lifespan • The molecules involved in cross-talk between DC and other cells and tissues • The mechanisms of DC interactions with the tumor microenvironment • The DC regulatory pathways regulating immunity versus tolerance
Organized by: Muriel Moser, Caetano Reis e Sousa and Yong-Jun Liu
Invited Speakers: - Shizuo Akira, Osaka University
- Matthew Albert, Institut Pasteur
- Sebastian Amigorena, Institut Curie
- Jacques Banchereau, Baylor Institute for Immunology Research
- Vincenzo Cerundolo, Institute of Molecular Medicine
- Lieping Chen, Johns Hopkins School of Medicine
- Marco Colonna, Washington University School of Medicine
- Pierre Coulie, University of Louvain, Brussels
- Carl Figdor, University Medical Center of Nijmegen/NCMLS
- Takashi Fujita, Institute for Virus Research, Kyoto University
- William Heath, Walter and Eliza Hall Institute of Medical Research
- Tsuneyasu Kaisho, RIKEN
- Bart Lambrecht, Erasmus University
- Yong-Jun Liu, University of Texas MD Anderson Cancer Center
- Diane Mathis, Harvard Medical School
- Ruslan Medzhitov, Yale University School of Medicine
- Ira Mellman, Yale University School of Medicine
- Muriel Moser, Université Libre de Bruxelles
- Anne O'Garra, National Institute for Medical Research
- Pamela Ohashi, Ontario Cancer Institute/University Health Network
- Dana Philpott, University of Toronto
- Fiona Powrie, University of Oxford
- Gwendalyn Randolph, Mount Sinai School of Medicine
- Caetano Reis e Sousa, Cancer Research UK, London Research Institute
- Kenneth Rock, University of Massachusetts Medical School
- Alexander Rudensky, University of Washington School of Medicine
- Stephen Schoenberger, La Jolla Institute for Allergy and Immunology
- Gerold Schuler, University of Erlangen
- Ralph Steinman, Rockefeller University
- Tadatsugu Taniguchi, University of Tokyo
- Jürg Tschopp, University of Lausanne
- Dale Umetsu, Children's Hospital Boston
- Maries van den Broek, Institute of Experimental Immunology, University Hospital Zurich
- Yvette van Kooyk, Vrije University Medical Center
- Colin Watts, University of Dundee
- Laurence Zitvogel, Institut Gustave Roussy
Deadline for Abstracts: Oct. 25, 2006
Registration: Please see website
E-mail: info@keystonesymposia.org
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