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Genome Instability and Repair

  June 15, 2006  

Keystone Symposia, Breckenridge, Colorado
January 17 - 22, 2007

Genomic instability is a key event in aging, cancer and some heritable diseases. Highly conserved pathways have evolved to detect the presence of genome damage and to effect its repair. This meeting will explore recent advances in our understanding of the nature and causes of genomic instability, the mechanisms of DNA repair, and the consequences of failure in DNA repair with regard to human health and disease. The program will emphasize advances that provide mechanistic understanding of pathways that maintain genomic integrity, and the intersection of these pathways with normal cellular development, aging, and tumorigenesis. The molecular and mechanistic emphasis is designed to attract a broad cross-section of researchers. The goals of this meeting are to identify new avenues for investigation, to define therapeutic strategies for maintenance of genomic integrity, to stimulate collaborations, and to foster the long-term development of this rapidly emerging research area by encouraging participation of young investigators.
Organized by: Nancy Maizels, Ian D. Hickson and David B. Roth
Invited Speakers: - Andrés Aguilera, Universidad de Sevilla
- Geneviève Almouzni, Centre National de la Recherche Scientifique
- Frederick Alt, Children's Hospital Boston
- Jiri Bartek, Danish Cancer Society
- Maria Blasco, Centro Nacional de Investigaciones Oncologicas
- Vilhelm Bohr, NIA, National Institutes of Health
- Keith Caldecott, University of Sussex
- Judith Campisi, Lawrence Berkeley National Laboratory
- Ronald DePinho, Dana Farber Cancer Institute
- Myron Goodman, University of Southern California
- Curtis Harris, National Institutes of Health
- Ian Hickson, University of Oxford
- Jan Hoeijmakers, Erasmus University
- Maria Jasin, Memorial Sloan-Kettering Cancer Center
- Michael Kastan, St. Jude Children's Research Hospital
- Michael Lichten, National Institutes of Health
- Guillermina Lozano, University of Texas MD Anderson Cancer Center
- Nancy Maizels, University of Washington School of Medicine
- Peter McKinnon, St. Jude Children's Research Hospital
- Raymond Monnat Jr., University of Washington
- Bertrand Nadel, CNRS-INSERM, - Universite de la Medditerranee
- Michael Neuberger, Medical Research Council
- André Nussenzweig, National Institutes of Health
- Tanya Paull, University of Texas at Austin
- David Roth, New York University School of Medicine
- Graeme Smith, KuDOS Pharmaceuticals Ltd.
- John Tainer, The Scripps Research Institute
- Minoru Takata, Kawasaki Medical School
- Craig Thompson, Abramson Family Cancer Research Institute, University of Pennsylvania
- Gregory Verdine, Harvard University
- Stephen West, Cancer Research UK
Deadline for Abstracts: Sept. 18, 2006
Registration: Please see website
E-mail: info@keystonesymposia.org
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