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Keystone Symposia, Steamboat Springs, Colorado
January 5 - 10, 2007
The JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathways play an important role in a wide variety of biological processes. Most cytokines and many growth factors exert their biological functions via JAK/STAT signaling. The significance of JAK/STAT signaling is further underscored by the fact that aberrant JAK/STAT signaling is associated with human diseases such as immune disorders and tumorigenesis. Tyrosine phosphorylation of JAKs and STATs is a well established activator in these pathways, but STAT activity is also modulated by serine phosphorylation and, possibly, by methylation and acetylation as well. The identities and roles of the additional signal transduction pathways that might contribute to these modifications and other regulatory interactions are the subject of much current investigation. This meeting will focus on the following key aspects of current research in JAK/STAT signaling, particularly with regard to its role in immune function: recent advances in understanding the regulation of JAK activity, STAT nuclear translocation, the role of non-tyrosine- phosphorylated STATS, and negative regulation of the pathway; dissection and analysis of pathways that interact with JAKS and STATS in immune responses; links between the JAK/STAT pathway and innate immune receptors (e.g. Toll-like receptors) through type I interferon synthesis which, in turn, suggest critical roles of JAK/STAT target genes in the regulation of innate and adaptive immune response; and the role of JAK/STAT pathways in cancer will also play an important role.
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Organized by:
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Thomas A.F. Decker, Christian W. Schindler and David E. Levy |
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Invited Speakers:
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- James Darnell Jr., Rockefeller University
- Thomas Decker, Vienna Biocenter
- Takashi Fujita, Institute for Virus Research, Kyoto University
- Gary Gilliland, National Institute of Standards and Technology
- Douglas Hilton, Walter and Eliza Hall Institute of Medical Research
- David Levy, New York University School of Medicine
- Tom Maniatis, Harvard University
- Matthias Müller , Veterinary University of Vienna
- John O'Shea, NIAMS, National Institutes of Health
- Norbert Perrimon, Harvard Medical School
- Nancy Reich, Stony Brook University
- Christian Schindler, Columbia University
- Robert Schreiber, Washington University School of Medicine
- Veronika Sexl, University of Vienna
- Olli Silvennoinen, University of Tampere
- Giulio Superti-Furga, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences
- Uwe Vinkemeier, Leibniz- Forschungsinstitut für Molekulare Pharmakologie
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Deadline for Abstracts:
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Sept. 13, 2006
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Registration:
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Please see website
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E-mail:
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info@keystonesymposia.org
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