Welcome to 3rd Tumor Progression & Therapeutic Resistance - 2006

6:45 Breakfast and Registration

CRITICAL EVENTS IN TUMOR PROGRESSION

7:30 Oncogenesis and Therapeutics in 3D Breast Epithelial Model Joanne Brugge, Harvard University

7:55 GSK3beta and Snail in the Epithelial to Mesenchymal Transition Mien-Chie Hung, MD Anderson Cancer Center


8:20 The Epigenetic Influence of the Microenvironment on Reprogramming the Metastatic Phenotype
Mary Hendrix, Northwestern University

10:45 Refreshment Break and Poster Viewing
TUMOR MICROENVIRONMENT, INFLAMMATION AND STEM CELLS

9:00 Normalizing the Tumor Microenvironment using Antiangiogenic Therapy
Rakesh Jain, Massachusetts General Hospital


9:25 Inflammation and Cancer
Michael Karin, University of California, San Diego

9:50 Mammary Cell Progenitor Stem Cells
Vimla Band, Northwestern University


10:15 TBD Nelly Polyak, Dana Farber Cancer Institute

10:40 Refreshment Break and Poster Viewing

PRE-CLINICAL MODELS OF HUMAN CANCER

11:00 Animal Models of Nuclear Cyclin D1 as an Oncogene and Target for Therapy
Alan Diehl, University of Pennsylvania

11:25 Reversible Tumorigenesis and Tumor Maintenance
Gerard Evan, University of California, San Francisco

11:50 TBD Ramon Parsons, Columbia University

12:15 **LUNCH SESSION**

Leveraging Resources and Realigning Priorities with Limited Resources (Doing More with Less)
Moderator: Bruce Zetter, Children’s Hospital of Boston

MECHANISMS OF THERAPEUTIC RESISTANCE

2:00 Understanding the Simple Complexities of Drug Resistance
Tito Fojo, National Cancer Institute

2:25 Mechanisms of Primary and Secondary Resistance to EGFR Tyrosine Kinase Inhibitors
William Pao, Memorial Sloan-Kettering Cancer Center

2:50 p73 and Tumor Resistance
Gerry Melino, University of Rome

3:15 Refreshment Break and Poster Viewing

3:30 p53/NFkB Relationship in Tumors
Andrei Gudkov, Cleveland Clinic Foundation

3:55 ADAM Proteases, ErbB Pathways and Cancer
Bin-Bing Zhou, Incyte Corp.


4:20 Poster Session


6:00 Dinner

MOLECULAR TARGETS FOR THERAPY

7:00 Role of Cell Death in Tumorigenesis: Identifying Genetic Determinants of Chemotherapeutic Response
Eileen White, Rutgers University

7:25 Mechanisms of Cancer Cell Resistance to Apoptosis by the Tumor Suppressor Par-4
Vivek Rangnekar, University of Kentucky

7:50 Targets for Therapy in Pancreatic Cancer
Scott Kern, Johns Hopkins University

8:15 Aberrant Methylation as a Therapy Target
Peter Jones, University of Southern California

8:40 Chemoprevention
Mark Nelson, University of Arizona

9:00 Poster Viewing


Day Three: Tuesday, September 20, 2005

6:45
Breakfast and Registration

TECHNOLOGIES FOR DRUG DISCOVERY AND PRE-CLINICAL VALIDATION

7:30 Functional Genomics in Prostate and Breast Cancer
Arul Chinnayan, University of Michigan

7:55 Genetic Dependency and Targeted Cancer Therapeutics: Lessons from Integrated Genomics
Levi Garraway, Dana Farber Cancer Institute


8:20 Oral Presentations from Selected Abstracts

9:50 Refreshment Break and Poster Viewing

IMAGING, THERAPEUTICS, AND METASTASIS TARGETING

10:00 Detecting and Targeting Boney Metastases
Ken Pienta, University of Michigan

10:55 Biomarkers and Imaging Endpoints to Accelerate Oncologic Drug Development
Gary Kelloff, NCI, NIH

11:20 Refreshment Break and Poster Viewing

CELLULAR DAMAGE AND REPAIR SIGNALING

11:50 TBD
Martin Brown, Stanford University

12:30 TBD
Arnold Levine, Institute for Advanced Studies

1:00 Lunch

NEW DRUGS AND COMBINATIONS IN PRE-CLINICAL AND CLINICAL TESTING

2:00 CTLA4 Blockade in Cancer Therapy
Stephen Eck, Pfizer, Inc.

2:25 Targeting the IGF-1R Signaling Pathway: Neutralizing Human anti-IGF-1R Antibody
Yan Wang, Schering Plough Research Institute

2:50 MSC as Gene Delivery Vehicles
Michael Andreef, MD Anderson Cancer Center

3:15 Novel Non-ATP Competitive Kinase Inhibitors
Prem Reddy, Temple University

3:35 Conference Concludes

Steven Eck
Pfizer, Inc.

Joanne Brugge
Harvard University

Mien-Chie Hung
MD Anderson Cancer Center

Rakesh Jain
Harvard University

Kornelia Polyak
Dana Farber Cancer Center

William Pao
Memorial Sloan Kettering Cancer Center

Gerry Melino
University of Rome

Alan Diehl
University of Pennsylvania

Gerard Evan
University of California, San Francisco

Arul Chinnayan
University of Michagan

Eileen White
Rutgers University

Scott Kern
Johns Hopkins University

Peter Jones
University Of Southern California

Ken Pienta
University Of Michigan

Martin Brown
Stanford University

Arnold Levine
Institute for Advanced Studies

Prem Reddy
Temple University

Michael Andreef
MD Anderson Cancer Center

Bruce Zetter
Children's Hospital of Boston

Gary Kelloff
National Cancer Institute, NIH

Mary Hendrix
Northwestern University

Michael Karin
University of California, San Diego

Wafik El-Deiry
University of Pennsylvania, Conference Chairperson

Vimla Band
Northwestern University

Rakesh Jain
Massachusetts General Hospital

Ramon Parsons
Columbia University

Tito Fojo
National Cancer Institute

Levi Garraway
Dana Farber Cancer Institute

Andrei Gudkov
Cleveland Clinic Foundation

Vivek Rangnekar
University of Kentucky

Commercial - $1495.00
Academic/gov - $695.00
Students - $595.00

Early registration discount

20% off if you register two months before the meeting date. 10% off if you register one month before the meeting date.